Pancreatic Cancer Clinical Trial
Official title:
Study Of Post-Operative Concomitant Radio-Chemotherapy With A Continuous Infusion Of Flourouracil For Adjuvant Treatment Of Resected Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor
cells. Combining chemotherapy with radiation therapy may kill more tumor cells left after
surgery.
PURPOSE: Phase II trial to study the effectiveness of combining fluorouracil and radiation
therapy in treating patients who have undergone surgery for pancreatic cancer.
OBJECTIVES:
- Determine the tolerance of adjuvant fluorouracil with concurrent radiotherapy in
patients with resected pancreatic adenocarcinoma.
- Determine survival without local relapse in these patients treated with this regimen.
- Determine overall survival of these patients treated with this regimen.
- Determine the effectiveness of this adjuvant therapy in these patients.
OUTLINE: This is a multicenter study.
Patients receive high-dose radiotherapy 5 days a week for 5 weeks. Patients also receive
low-dose radiotherapy 4 times a week during the last 2 weeks of the 5-week course of
treatment. Patients concurrently receive fluorouracil IV continuously for 5 weeks in the
absence of disease progression or unacceptable toxicity.
Patients are followed for survival.
PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study.
;
Primary Purpose: Treatment
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