Pancreatic Cancer Clinical Trial
Official title:
Phase II Trial of ISIS 2503, an Antisense Inhibitor of H-Ras, in Patients With Advanced Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of ISIS 2503 in treating patients who
have advanced cancer of the pancreas.
OBJECTIVES: I. Determine the response rate and time to progression in patients with advanced
adenocarcinoma of the pancreas who are treated with ISIS 2503. II. Determine the duration of
response in these patients receiving this regimen. III. Characterize the safety profile of
ISIS 2503 at the recommended phase II dose and schedule in these patients.
OUTLINE: Patients receive ISIS 2503 IV continuously for 14 days. Treatment continues every
21 days for a minimum of 3 courses in the absence of unacceptable toxicity or disease
progression.
PROJECTED ACCRUAL: A total of 14-27 patients will be accrued for this study within 12
months.
;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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