Pancreatic Cancer Clinical Trial
Official title:
A Phase I Pilot Trial of Immunotherapy With Autologous Tumor-Derived gp96 Heat Shock Protein - Peptide Complex (HSPPC-96) in Patients With Resected Pancreatic Adenocarcinoma
RATIONALE: Vaccines made from a person's cancer cells may make the body build an immune
response to and kill tumor cells. Combining vaccine therapy with surgery may be an effective
treatment for pancreatic cancer.
PURPOSE: Phase I trial to study the effectiveness of vaccine therapy in treating patients
with stage I or stage II pancreatic cancer that has been surgically removed.
OBJECTIVES: I. Study the safety of autologous tumor derived gp96 heat shock protein peptide
complex (HSPPC-96) in patients with resected pancreatic adenocarcinoma. II. Examine the
immune response to HSPPC-96 in this group of patients.
OUTLINE: This is a dose escalation study. Six weeks after surgery patients are given
autologous tumor derived gp96 heat shock protein peptide complex (HSPPC-96) subcutaneously
once a week for 4 weeks. Five patients are initially enrolled at each of two dose levels. An
additional three patients may be enrolled at each dose level to determine the optimal dose
of HSPPC-96. Patients are followed at weeks 1, 4, and 12 after treatment.
PROJECTED ACCRUAL: A maximum of 16 patients will be accrued for this study.
;
Primary Purpose: Treatment
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