Is There a Pancreatic Segmentation Based on the Pancreatic Duct Branching?

Pancreas Clinical Trial

Official title:

The Pancreas and the Bilio-pancreatic Junction: Is There a Pancreatic Segmentation Based on the Pancreatic Duct Branching?

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03348319
• Other study ID #: PA16146
• Status: Recruiting
• Start date: October 22, 2018
• Est. completion date: April 1, 2021

Study information

• Verified date: April 2019
• Source: CHU de Reims
• Contact: Yohann RENARD
• Phone: 326787123
• Email: yrenard[@]chu-reims.fr
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Limited pancreatic resections are increasingly performed, but the rate of postoperative fistula is higher than after classical resections. Pancreatic segmentation, anatomically and radiologically identifiable, may theoretically help the surgeon removing selected anatomical portions with their own segmental pancreatic duct and thus might decrease the postoperative fistula rate. Current pancreatic segmentation theories do not enable defining anatomical-surgical pancreatic segments. To our knowledge, no study has tried to describe pancreatic segmentation from the divisions of the pancreatic ducts to date. Hence, we hypothesize to explore the possibility of pancreatic segmentation following pancreatic ducts, using extensive reconstructions of pancreatic duct using micro-scanner on injected human pancreas.

Description:

• In a first step, the injection technique will be developed (dilution, stability, hardening of the contrast mixture).

• In a second step, we will inject the mixture in human pancreas: into the duct tree, the vein and arteries. After hardening, the human pancreas will be removed from cadavers following the organ donation technique. The anatomic specimens will be scanned in the laboratory UMR CNRS 7369 MEDyC, Reims (Pr X. MAQUART, Dr J. DEVY).

• The images obtained (Dicom format) are very big in term of file size. Analysis of the images will be performed using a supercomputer of the laboratory CReSTIC - ROMEO EA 3804, Reims (Dr A. RENARD, Pr M. KRAJEKI). 3D reconstructions will be performed.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 20
• Est. completion date: April 1, 2021
• Est. primary completion date: April 1, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

inclusion criteria :

• All consecutive cadavers donated to the Department of Anatomy, Faculty of Medicine and University Hospital, Champagne-Ardenne University for anatomical education and research will be studied. These cadavers will be studied following all the ethical rules of work on cadaver material in our institution.

exclusion criteria :

• Cadavers not usable due to learning necessity, to failure of conservation, dissection difficulties.

Related Conditions & MeSH terms

• Pancreas

Intervention

Other:
• radiation
Scanning cadaver organs

Locations

Country	Name	City	State
France	Chu Reims	Reims

Sponsors (1)

Lead Sponsor	Collaborator
CHU de Reims

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Size of the ducts	The anatomic specimens will be scanned. The images will be analysed	baseline
Primary	Number of branching	The anatomic specimens will be scanned. The images will be analysed	baseline