Kidney Transplantation Clinical Trial
Official title:
Contrast Enhanced Ultrasound Scanning of Kidney and Pancreas Transplantation (Proof of Principle Study)
This study is to investigate whether it is possible to use a special type of ultrasound scan
(CEUS, Contrast Enhanced Ultrasound Scan) to view the shape, assess blood supply and
calculate the amount of oxygen being carried to a transplanted kidney and pancreas. We
currently use a nuclear scan (Transcan) to assess this in the kidney. This is cumbersome,
involves nuclear medicine and takes 45- 60 minutes to complete.
We do not routinely image the blood supply to the pancreas post-surgery, despite the most
common complication post pancreas transplantation being vascular in origin. In an emergency
a CT angiogram is carried out. This involves transfer of a sick patient to the CT scanner
and injection of contrast which is harmful to the kidneys.
CEUS involves injection of a safe contrast prior to conducting an ultrasound scan. This can
be carried out at the bed-side, provides instant results and is cheap and safe enough to do
on a routine basis for all kidney and pancreas transplant recipients. Although the uses of
CEUS are well recognised, it is currently not routinely used in transplantation. CEUS has
been compared to other modes of imaging and has been found to be comparable/ beneficial.
However, it has never been compared to Transcan. We will therefore perform CEUS on our
kidney transplant recipients and compare the results to Transcan. We will also assess
whether CEUS is able to visualise the blood supply to the kidney and pancreas and quantify
the perfusion to the pancreas.
n/a
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