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Clinical Trial Summary

This pilot study aims to validate the use of vascularised donor-derived sentinel skin flaps for diagnosing rejection in pancreas transplantation. The aim of the study is to investigate the use of sentinel skin flaps in clinical practice and assess whether rejection occurs concordantly or discordantly between the skin flap and the transplanted abdominal organs. If successful, sentinel skin may allow improved immune surveillance and thereby facilitate earlier treatment of rejection with subsequent improvements in allograft survival and patient morbidity.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03183258
Study type Interventional
Source University of Oxford
Contact James CH Barnes
Phone +447717707384
Email James.Barnes@nds.ox.ac.uk
Status Recruiting
Phase Phase 1/Phase 2
Start date May 19, 2016
Completion date October 1, 2020

See also
  Status Clinical Trial Phase
Completed NCT04130685 - Donor-Derived Cell-Free DNA for Surveillance in Simultaneous Pancreas and Kidney Transplant Recipients