Pancreas Neoplasm Clinical Trial
— NLROfficial title:
The Neutrophil-to-Lymphocyte Ratio at Post-operative Day 3: a Simple Tool to Exclude Clinically Relevant Postoperative Pancreatic Fistula After Pancreatoduodenectomy
Verified date | January 2021 |
Source | Institut Paoli-Calmettes |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
There is still no consensus on whether drain fluid amylase (DFA) level, C-reactive protein (CRP) level, or complex scores predict clinically relevant postoperative pancreatic fistula (CR-POPF). The aim of this study is to determine the accuracy of simple biochemical parameters (leucocytes, neutrophils, lymphocytes, Neutrophil to Lymphocytes Ratio (NLR), at postoperative days 1 and 3) to exclude the diagnosis of CR-POPF.
Status | Completed |
Enrollment | 648 |
Est. completion date | February 28, 2021 |
Est. primary completion date | December 31, 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Patients who underwent pancreatoduodenectomy Exclusion Criteria: - Total pancreatectomy - Enucleation |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Institut Paoli-Calmettes |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Incidence of clinically relevant pancreatic fistula | Clinically relevant postoperative pancreatic fistula according to the 2016 International Study Group of Pancreatic Surgery definition | at hospital discharge assessed up to 30 days | |
Secondary | Biological markers | Identification of biological markers to exclude clinically relevant postoperative pancreatic fistula | Postoperative day one and three |
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