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The Neutrophil-to-Lymphocyte Ratio to Exclude Pancreatic Fistula — NLR  

Pancreas Neoplasm Clinical Trial

Official title:
The Neutrophil-to-Lymphocyte Ratio at Post-operative Day 3: a Simple Tool to Exclude Clinically Relevant Postoperative Pancreatic Fistula After Pancreatoduodenectomy

Clinical Trial Summary

There is still no consensus on whether drain fluid amylase (DFA) level, C-reactive protein (CRP) level, or complex scores predict clinically relevant postoperative pancreatic fistula (CR-POPF). The aim of this study is to determine the accuracy of simple biochemical parameters (leucocytes, neutrophils, lymphocytes, Neutrophil to Lymphocytes Ratio (NLR), at postoperative days 1 and 3) to exclude the diagnosis of CR-POPF.

Clinical Trial Description

From January 1, 2012 to December 31, 2020, consecutive patients underwent PD performed at Institut Paoli-Calmettes for various pathologies. Data were entered prospectively into a clinical database (NCT02871336). The cohort was split into 3 groups: - a training cohort ; - an internal validation cohort (Paoli Calmettes institute); - an external validation cohort (Rennes Pontchaillou Hospital). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04724551
Study type Observational
Source Institut Paoli-Calmettes
Contact
Status Completed
Phase
Start date June 1, 2012
Completion date February 28, 2021
View Details
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