Pancreas Adenocarcinomas Clinical Trial
Official title:
Prospective Evaluation of the Role of MRI in the Perioperative Management of Pancreas Adenocarcinomas
The precision of MRI has improved over the past few years, in particular for the
hepatobiliary and pancreatic pathologies. The role of MRI in the management of operated
pancreas tumors remains nevertheless unclear and few studies have compared MRI to the actual
gold standard (CT). Compared to CT, MRI is not only a morphologic imaging technique but also
a functional imaging technique. MRI could therefore evaluate in a non-ionizing and dynamic
way several important pre- and postoperative aspects after pancreaticoduodenectomy (PD). This
study on the perioperative role of MRI includes 3 parts:
First, CT is known to minimize the real size of the pancreatic tumors and to underestimate
the vascular invasion correlated to resectability. The preoperative determination of the
resection surgical margins could be improved thanks to the high-contrast resolution of MRI.
Moreover, PD is a complex surgery encompassing a fragile anastomosis between the pancreatic
parenchyma and the digestive tract. The permeability of the pancreatic anastomosis after PD
remains presently unknown and has not been correlated to the clinical state of the patient.
MRI associated with secretin injection allows evaluating this permeability, which cannot be
done by CT due to the absence of functional evaluation.
Finally, present radiological follow-up after PD for tumors of the pancreatic head is
performed with CT. The MRI performance has not been demonstrated yet in the context of
follow-up. This imaging modality nevertheless offers unique specificities that are very
interesting and that could be helpful for the diagnosis of recurrence.
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