Palliative Radiotherapy Clinical Trial
— ASPIRE_MultiOfficial title:
Advanced Techniques For Single-fraction Palliative Radiotherapy Versus Standard Multi Fraction Radiation
The aim of the study is to determine if single fraction dose escalated palliative radiotherapy results in a prolonged duration of benefit for patients otherwise suitable for Multifraction (5-10#) palliative radiation. The primary endpointis to determine the percentage of patients who have achieved a substantial benefit from palliative radiotherapy and have not redeveloped symptoms by 12 months post treatment
Status | Recruiting |
Enrollment | 100 |
Est. completion date | June 30, 2025 |
Est. primary completion date | June 30, 2025 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A and older |
Eligibility | Inclusion Criteria: - Metastatic cancer - Recommended for 5-10 fractions palliative radiation - Patients with spinal cord compression are eligible for enrolment Exclusion Criteria: - Unwilling or unable to give informed consent - Patients who are recommended for single fraction palliative radiation |
Country | Name | City | State |
---|---|---|---|
Australia | Royal North Shore Hospital | Saint Leonards | New South Wales |
Lead Sponsor | Collaborator |
---|---|
Royal North Shore Hospital |
Australia,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | benefit from palliative radiotherapy | to determine the percentage of patients who have achieved a substantial benefit from palliative radiotherapy and have not redeveloped symptoms by 9 months post treatment | 9 months | |
Secondary | Feasibility of the trial | This will be assessed by the treatment wait time, the amount of time spent in the Radiation Department, the completion rates of electronic Patient Reported Outcome (ePRO)'s and comparing patient and carer assessments | 2 years | |
Secondary | Trial Safety | this will be determined by the radiation dose delivered to organs at risk and patient and carer reported toxicity from treatment | 2 years | |
Secondary | Efficacy of treatment | Efficacy will be determined by reported treatment benefit, pain response, symptom control,re-treatment rates, overall survival and patient and carer regret | 2 years |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04133415 -
Palliative Lattice Stereotactic Body Radiotherapy (SBRT)
|
N/A | |
Recruiting |
NCT04658537 -
Advanced Techniques for Single-fraction Palliative Radiotherapy Versus ASPIRE-single
|
N/A |