Clinical Comparison of Application of Curcumin Gel in Pain Management After Free Gingival Graft Harvesting

Palate; Wound Clinical Trial

— curcumin  

Official title:

Clinical Comparison of Topical Application of Curcumin Gel Versus Gelatin Sponge in Pain Management and Wound Healing After Free Gingival Graft Harvesting: a Randomized Controlled Clinical Trial

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05819632
• Other study ID #: CairoU28122022
• Status: Recruiting
• Phase: N/A
• Start date: November 1, 2022
• Est. completion date: April 1, 2024

Study information

• Verified date: April 2023
• Source: Cairo University
• Contact: Tansim k ABdelrahman, BDS
• Phone: +201001086940
• Email: tansim.khaled[@]denistry.cu.edu.eg
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of this study is to compare the effect of using 2% curcumin gel versus gelatin sponge when applied to palatal donor site in pain management and wound healing after free gingival graft harvesting.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: April 1, 2024
• Est. primary completion date: February 1, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

1. Systematically healthy patient (American Society of Anesthesiology class I and II).

2. Male or female

3. Patients with mucogingival defects scheduled for free gingival graft.

4. Patients with good oral hygiene.

Exclusion Criteria:

1. Patients with any uncontrolled local or systemic disease where periodontal plastic surgery might be contraindicated.

2. History of recent periodontal surgery at the donor site.

3. Smokers.

4. Pregnancy and lactation.

5. Patients allergic to the used agents,

6. Severe gagging reflex.

7. Inability or unwillingness to provide informed consent.

Related Conditions & MeSH terms

• Palate; Wound

Intervention

Other:
• curcumin gel 2%
curcumin gel 2%

Locations

Country	Name	City	State
Egypt	Faculty of Dentistry	Cairo	Manial

Sponsors (1)

Lead Sponsor	Collaborator
Cairo University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	post-operative pain	post -operative pain measured by visual analouge scale from 0 (no pain) to 10 (highest pain value)	one week post operative
Secondary	Soft tissue healing of the palatal wound	Soft tissue healing of the palatal wound measured by Modified Landry's wound healing score from 1 indicates poorest healing to 5 indicates excellent healing	up to three weeks post-operative
Secondary	Re-epithelization of the palatal wound	Re-epithelization of the palatal wound using H2O2 test	up to three weeks post-operative