S-ketamin Premedication in Pediatric EENT Surgery

Status Completed

Clinical Trial Summary

We aim to investigate the effects of premedication (intranasal or intravenous administration) of s-ketamin, dexmedetomidine, and combination for premedication in children undergoing ENT surgery.

Clinical Trial Description

Three hundred children aged between 2 and 12 years were randomly allocated to one of five groups: 0.3 μg/kg intravenous injection s-ketamin; 0.5 μg/kg intravenous injection s-ketamin; 2 μg/kg intranasal s-ketamin group; 1 μg/kg intranasal s-ketamin + 1 μg/kg intranasal dexmedetomidine group; 0.5 μg/kg intranasal s-ketamin + 2 μg/kg intranasal dexmedetomidine group. The modified Yale Preoperative Anxiety Scale (m-YPAS) was used to assess preoperative anxiety at 1, 5, 10, 20, and 30min after premedication. A 4-point emotional state score was used to evaluate participators when they were separated from their parents and their response to intravenous cannulation or facemask application. Agitation scores (Pediatric Anesthesia Emergence Delirium [PAED] scale) and POV was assessed in the postanesthetic care unit (PACU). Times to endotracheal tube or laryngeal mask airway removal, discharge from the PACU, and patients' satisfaction degree were also assessed. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04757675
Study type	Interventional
Source	Eye & ENT Hospital of Fudan University
Contact
Status	Completed
Phase	Early Phase 1
Start date	March 1, 2021
Completion date	January 1, 2022

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04680611` - Severe Asthma, MepolizumaB and Affect: SAMBA Study
Completed	`NCT04150952` - HRV-based Training Effects in Athletes	N/A
Not yet recruiting	`NCT06071130` - Emotion, Aging, and Decision Making	N/A
Not yet recruiting	`NCT06317844` - Examination of Psychological and Physiological Pathways Linking Gratitude and Pain	N/A
Completed	`NCT01629069` - A Transplant or Cancer Resilience Intervention	N/A
Completed	`NCT01786083` - Caring for Family Caregivers:a Research-action Study	N/A
Recruiting	`NCT05391295` - Mapping Emotional Dynamics During Corticosteroid Treatment
Recruiting	`NCT05949047` - Smartphone-based Cognitive Emotion Regulation Training for Unpaid Primary Caregivers of Persons With Alzheimer's Disease	N/A
Completed	`NCT03681509` - Pramipexole and Emotional Processing	N/A
Completed	`NCT03220204` - Researching Emotions And Cardiac Health: Phase III	N/A
Completed	`NCT01909895` - Study of the Effects of Negative Emotions on Endothelial Function	N/A
Completed	`NCT04465240` - Adolescent Responses to Varying Environments in Virtual Reality Simulations	N/A
Recruiting	`NCT06056674` - Unified Protocol for Preventing Emotional and Academic Challenges in Education (U-PEACE)	N/A
Completed	`NCT03781921` - The Neural Bases of Emotion Regulation in Bulimia Nervosa
Recruiting	`NCT03293537` - Dementia Associated Apathy.	N/A
Active, not recruiting	`NCT05542498` - Promoting Stress Management and Engagement in Introductory Physics Courses With Mindfulness and Relaxation	N/A
Not yet recruiting	`NCT05595005` - Neural Bases of Post-stroke Emotion Perception Disorders
Completed	`NCT02509559` - Effects of Propranolol (vs. Placebo) on Information Processing During Presentation of Emotionally Arousing Pictures	Phase 1
Completed	`NCT06051500` - Psychological and Physiological Effects of Different Objects of Breath Meditation	N/A
Recruiting	`NCT05363852` - Questionnaire and Projective Color Association in Physiological Responses to Different Emotional Charge	N/A