Pain Measurement Clinical Trial
Official title:
Comparison Between Dexamethasone and Ibuprofen on Postoperative Pain Prevention and Control Following Surgical Implant Placement: a Double-Blind, Parallel-Group, Placebo-Controlled Randomized Clinical Trial
Background and aim: Postoperative pain is an adverse effect of oral surgeries and may
therefore be prevented or minimized. This study compares the efficacy of preemptive
ibuprofen and dexamethasone protocols in pain prevention and control after surgical implant
placement.
Methods: For this prospective, double-masked, parallel-group, placebo-controlled, randomized
clinical trial, 117 dental implants were placed. The groups received three different
protocols 1 hour before surgery:
1. 600 mg ibuprofen (and another 600 mg dose 6 hours after the first dose);
2. 4 mg dexamethasone (and another 4 mg 6 hours after the first dose) or
3. placebo.
Rescue medication (1000 mg acetaminophen) was given to each patient who was instructed to
take it if necessary. Pain intensity was evaluated by a 101-point numeric rate scale and
visual analogue scale, additionally discomfort was evaluated using a four-point verbal rate
scale, hourly for the first 8 hours after surgery and three times a day on the following 3
days.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Outcomes Assessor), Primary Purpose: Prevention
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