Pain Insensitivity, Congenital Clinical Trial
Official title:
Comparative Evaluation of Newer Congeners i.e. Levobupivacaine and Ropivacaine With Bupivacaine, in Lumbar Epidural Anaesthesia for Hip Surgeries
This study compares the clinical efficacy of newer local anaesthetic drugs Levobupivacaine and Ropivacaine with Bupivacaine in lumbar epidural anaesthesia for hip surgeries.
Some of the most common day care surgeries are hip surgeries, in which local anaesthetic
agents can be used via epidural route for both intra-op and post-op analgesia.
Among the drugs used nowadays are Lignocaine, Bupivacaine, Levobupivacaine and
Ropivacaine.However Bupivacaine usage is not free from side effects.
The claimed benefits of both Levobupivacaine and Ropivacaine are reduced cardiac toxicity on
overdose and more specific effects on sensory rather than motor nerve fibres.
Ropivacaine, an analog of Mepivacaine, is one of the long acting amide anaesthetic agent
similar to Bupivacaine in chemical structure and anaesthetic function. It is a first
enantiomer-specific compound, which has a reduced risk of cardio toxicity, neuro toxicity
and rapid recovery of motor function. Levobupivacaine is the pure S (−)-enantiomer of
Bupivacaine, and in recent year has emerged as a safer alternative for regional anaesthesia
than its racemic parent.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Supportive Care
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