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Pain, Acute clinical trials

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NCT ID: NCT03111342 Completed - Pain, Acute Clinical Trials

Intracervical Anesthesia and Pain Associated With Intrauterine Contraceptive Insertion

Start date: June 1, 2017
Phase: Phase 4
Study type: Interventional

The primary aim of our study is to evaluate the effect of intracervical anesthesia on pain scores immediately following levonorgestrel-releasing intrauterine system (LNG-IUS) insertion in nulligravida women.

NCT ID: NCT03107481 Completed - Pain, Acute Clinical Trials

Acetaminophen IV vs Hydromorphone IV in the ED

Start date: June 4, 2017
Phase: Phase 4
Study type: Interventional

The purpose of the current study is to compare the analgesic efficacy of intravenous acetaminophen and intravenous hydromorphone in the treatment of acute pain in the ED.

NCT ID: NCT03082417 Completed - Pain, Acute Clinical Trials

The PAINFREE Initiative, a Stepped Wedge Cluster Randomized Trial

PAINFREE
Start date: March 1, 2016
Phase: N/A
Study type: Interventional

The PAINFREE (Improving PAIN control following FRactures; towards an Elder-friendly Emergency department) Initiative is a patient-centered multifaceted intervention which aims to improve pain management in patients 75 years and older presenting with a fracture at 7 Emergency Department of participating Montreal hospitals: 1. Montreal General Hospital 2. Royal Victoria Hospital 3. Ste Mary's Hospital 4. Hôpital de Verdun 5. Hôpital du Sacré-Coeur de Montréal 6. Jewish General Hospital 7. Lakeshore General Hospital

NCT ID: NCT03080363 Completed - Pain, Acute Clinical Trials

Analgesic Efficacy of Ultrasound Guided Quadratus Lumborum Block During ESWL

Start date: March 15, 2017
Phase: Phase 4
Study type: Interventional

Extracorporeal shockwave lithotripsy (ESWL) is widely used for the treatment of urinary tract calculi; however, the vast majority of patients do not tolerate the procedure without analgesia and sedation. Lots of methods have been tried to control this pain (non-steroidal anti-inflammatory drugs, opioids, alpha 2 agonists, transversus abdominis plane block with long-acting local anesthetics, paravertebral block, local anesthetics infiltration, lidocaine/prilocaine cream). The quadratus lumborum block was first described by Blanco. QL block is performed as one of the perioperative pain management procedures for abdominal surgery. QL block provides anesthesia and analgesia on the anterior and lateral wall of the abdomen.

NCT ID: NCT03072888 Completed - Pain, Acute Clinical Trials

Effects of Transcutaneous Electrical Nerve Stimulation (TENS) Following Hysterectomy

Start date: March 31, 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the effect of Transcutaneous Electrical Nerve Stimulation (TENS) in patients after abdominal hysterectomy surgery.

NCT ID: NCT03071601 Completed - Pain, Acute Clinical Trials

Prospective Evaluation of Topical Analgesia for Laceration Repair in the Emergency Department

Start date: December 1, 2017
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine if topical analgesia using a lidocaine and prilocaine cream improves pain scores compared to the usual local anesthesia using subcutaneous 1% lidocaine and adrenalin injected near the laceration.

NCT ID: NCT03063359 Terminated - Pain, Acute Clinical Trials

Intranasal Fentanyl Versus Oral Morphine Sulfate in the Treatment of Pain in Pediatric Trauma

FINDOL
Start date: May 30, 2017
Phase: Phase 3
Study type: Interventional

Acute tramatic pain is one of main reasons for consultation in pediatric emergency departments. To manage pain quickly and effectively must be a primary outcome of the emergency department. However, pediatric emergency department are sometimes criticized for inadequate and delayed initiation analgesia . Indeed, several studies have shown the inadequacy between the intensity of the pain evaluated by the care team and the therapeutic management of it. The ideal analgesic must have a rapid onset of action, have a powerful analgesic effect, have few side effects and can be administered quickly and painlessly. That's why, the main outcome of this study is to assess the non inferiority of a treatment by intranasal Fentanyl vs morphine sulfate (oral use) in children with traumatic pain on arrival to pediatric emergency department.

NCT ID: NCT02997085 Completed - Pain, Acute Clinical Trials

Virtual Reality for Pain Management Study

Start date: January 2017
Phase: N/A
Study type: Interventional

Virtual Reality (VR) is one non-pharmacological method that has shown promise as an effective means of decreasing pain levels following treatment, and for significant periods of time. Additionally, neurobiology studies of VR have demonstrated a decrease in brain activity associated with pain. While VR is clearly a promising, drug-free option for pain treatment, existing VR systems are expensive and use unconvincing graphics. Recent advances in VR technology (i.e., improved realism and immersion using 360-degree 3D technology and more affordable delivery systems) allow the development of more realistic and more cost-effective applications. Capitalizing on these advances and the investigators' experiences with VR intervention development and evaluation, the current study will test a state-of-the-art VR experience in pain management intervention (Live-Action 360° Video Virtual Reality(VVR)) and compare it to established standard computer generated imagery (CGI) 360° VVR content for pain management intervention in a medical setting. The participant's participation will help the investigators determine which VR intervention is most effective in reducing acute pain in hospital patients.

NCT ID: NCT02980172 Completed - Pain, Acute Clinical Trials

Pain Evaluation and Treatment in the Emergency Department

Start date: November 2016
Phase: N/A
Study type: Observational

All patients admitted in Geneva University Hospitals (GUH) emergency department (ED) are triaged using the Swiss Emergency Triage Scale (SETS), a 4-level symptom-based triage scale. At the end of the triage process the triage nurse has to choose an emergency level and a main presenting complaint among a listing of 98 presenting complaints. The SETS recommends a pain evaluation for 44 out of the SETS 98 presenting complaint. The primary objective of the study is to determine whether pain is correctly evaluated when required by the SETS criteria. The secondary objectives are (1) to evaluate whether an appropriate treatment is delivered when pain is present, and (2) to identify predictors of pain evaluation and treatment.

NCT ID: NCT02976337 Completed - Healthy Subjects Clinical Trials

Effect of High-dose Naloxone Following Third Molar Extraction

TME
Start date: October 12, 2017
Phase: Phase 2
Study type: Interventional

Recent studies have focused on the role of endogenous opioids on central sensitization. Central sensitization is known to be impaired or altered in chronic pain conditions, as fibromyalgia or chronic tension headache. Animal studies have shown reinstatement of mechanical hypersensitivity following naloxone administration after resolution of an injury. This suggests latent sensitization. In the present study, the investigators hypothesize that a high-dose target-controlled naloxone infusion (total dose: 3.25 mg/kg) can reinstate pain and hyperalgesia 6-8 weeks after a unilateral primary open groin hernia repair procedure. The investigators aim to show that latent sensitization is present in humans and is modulated by endogenous opioids.