PAH Clinical Trial
Official title:
A Phase I, Open-label, Dose Escalation Study to Determine the Maximum Tolerated Dose and Evaluate the Safety, Tolerability and Pharmacokinetics of Single Doses of TransCon PEG Treprostinil Administered as a Subcutaneous Injection in Healthy Adult Male Volunteers
TransCon PEG treprostinil is a novel prodrug form of treprostinil, in which treprostinil is
reversibly conjugated via a four-arm branched polyethylene glycol (PEG) molecule. Reversible
coupling of treprostinil to PEG should allow for a modified extended pharmacokinetic profile
to achieve sustained plasma concentrations of treprostinil.
This will be the first investigation of TransCon PEG treprostinil in humans. This study aims
to determine the maximum tolerated dose (MTD) and assess the safety, tolerability and
pharmacokinetics of escalating single doses of a subcutaneous injection of TransCon PEG
treprostinil.
n/a
Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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