Pachyonychia Congenita Clinical Trial
Official title:
A Multicenter Open-Label Treatment Study Evaluating the Safety and Pharmacokinetics of QTORIN Rapamycin 3.9% Anhydrous Gel in the Treatment of Adults With Pachyonychia Congenita
PALV-08 is a multicenter, open-label treatment (OLT) study enrolling adults with Pachyonychia Congenita (PC) with genotyped keratin mutations KRT6A, KRT6B, KRT6C or KRT16 who were previously enrolled in the PALV-05 (VAPAUS) trial. The purpose of this OLT study is to investigate the safety of long term exposure and pharmacokinetics (PK) of QTORIN rapamycin 3.9% anhydrous gel or "PTX-022".
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02592954 -
Effect of Broccoli Sprout Extract on Keratinocyte Differentiation in Normal Skin
|
Phase 1 | |
| Active, not recruiting |
NCT04520750 -
VALO-2: Study Evaluating the Safety and Efficacy of PTX022 in the Treatment of Adults With Pachyonychia Congenita
|
Phase 3 | |
| Recruiting |
NCT05180708 -
A Multicenter, Phase 3 Randomized, Double-Blind, Vehicle-Controlled Study Evaluating the Safety and Efficacy of QTORIN 3.9% Rapamycin Anhydrous Gel in the Treatment of Pachyonychia Congenita
|
Phase 3 | |
| Recruiting |
NCT05956314 -
Assessment of KM-001 - Safety, Tolerability, and Efficacy in Patients With PPPK1 or PC
|
Phase 1 | |
| Not yet recruiting |
NCT01382511 -
Simvastatin Treatment of Pachyonychia Congenita
|
N/A | |
| Completed |
NCT02152007 -
Topical Sirolimus for the Treatment of Pachyonychia Congenita (PC)
|
Phase 1 | |
| Completed |
NCT00716014 -
Study of TD101, a Small Interfering RNA (siRNA) Designed for Treatment of Pachyonychia Congenita
|
Phase 1 | |
| Recruiting |
NCT02321423 -
International Pachyonychia Congenita Research Registry
|
||
| Active, not recruiting |
NCT03920228 -
Phase 2/3 Study Evaluating the Safety and Efficacy of PTX-022 in Treatment of Adults With Pachyonychia Congenita
|
Phase 2/Phase 3 |