Maternal Oxygen Administration for Fetal Distress

Status Completed

Clinical Trial Summary

Supplementary oxygen is routinely administered to patients, even those with adequate oxygen saturations, in the belief that it increases oxygen delivery. However, oxygen delivery depends not just on arterial oxygen content but also on perfusion.

Maternal oxygen administration has been used in an attempt to lessen fetal distress by increasing the available oxygen from the mother. However, the effect of supplemental maternal oxygen therapy on fetal acid base status has been debated for more than seven decades.

Hypothesis: Prophylactic maternal low flow nasal oxygen administration during the second stage of labor can relieve fetal distress.

Clinical Trial Description

A report from the cochran library (Cochrane Database Syst Rev. 2012 Dec 12;12:CD000136.):

Too little evidence to show whether oxygen administration to the woman during labour is beneficial to the baby.

Some babies show signs of distress, such as unusual heart rates or the passing of a bowel motion (meconium) during their mother's labour. This may be caused by a lack of oxygen passing from the woman to the baby through the placenta. Sometimes, women may be encouraged to breathe extra oxygen through a facemask (oxygen administration) to increase the oxygen available to the unborn baby. A review of two trials found too little evidence to show whether oxygen administration to the woman during the second stage of labour is beneficial to the baby. No trials of oxygen administration when the baby is showing signs of distress were found. Further research is needed. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02221440
Study type	Interventional
Source	Navy General Hospital, Beijing
Contact
Status	Completed
Phase	N/A
Start date	September 2014
Completion date	May 2015

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04325243` - Sildenafil Citrate and Intrapartum Fetal Distress	Phase 4
Completed	`NCT03095937` - Evaluation of Fetal Cardiac Function in Rheumatic Heart Disease (RHD) Patients
Completed	`NCT00185887` - Nitroglycerin Versus Terbutaline for Intrapartum Fetal Resuscitation	N/A
Completed	`NCT02862925` - Introducing Fetal Scalp Stimulation as an Adjunct to Intermittent Auscultation in Low-Resource Settings.	N/A
Recruiting	`NCT06186973` - Fetal Assessment of the Myocardium and Evaluation of the Neonate
Recruiting	`NCT05681624` - Maternal Oxygen Supplementation for Intrauterine Resuscitation	N/A
Completed	`NCT05946681` - Sildenafil Citrate to Improve Maternal and Neonatal Outcomes in Low-resource Settings
Completed	`NCT03536910` - Evaluation of Copeptin Levels in Elective Cesarean Section With Different Anesthetic Technique	N/A
Completed	`NCT03156608` - Novii External Fetal Monitoring Device	N/A
Recruiting	`NCT00246766` - Study of Fetal Movements Using Multichannel Ultrasound Pulsed Doppler in Normal and Pathologic Pregnancy	N/A
Recruiting	`NCT04043299` - Effect of Intrapartum Oxygen Administration on Fetal and Early Neonatal Outcomes	Phase 3
Not yet recruiting	`NCT03859037` - Effect of Umbilical Cord Milking on Transition of Preterm Babies During Resuscitation	N/A
Completed	`NCT03370822` - A Mixed Methods Study to Explore the Feasibility of a Novel Continuous Fetal Monitoring Device
Terminated	`NCT05147584` - Trans-abdominal Fetal Pulse Oximetry	N/A
Not yet recruiting	`NCT05727241` - Three-dimensional Umbilical Cord Coiling Index
Terminated	`NCT04081584` - Trans-abdominal Fetal Pulse Oximetry: Tissue Light Scattering
Completed	`NCT03764696` - Maternal Oxygen Administration for Fetal Distress II	N/A
Completed	`NCT01042262` - Maternal Oxygen Use During Delivery and Cord Blood Superoxide Dismutase	N/A
Not yet recruiting	`NCT04548453` - Establish the uSI Values and End-user Training Material That Will be Used to Guide Oxytocin Dosing Actions	Early Phase 1
Completed	`NCT03159234` - Prediction of Fetal Lung Maturity	N/A