Oxygen Inhalation Therapy Clinical Trial
Official title:
STIT-1 Evaluation of Safety and Efficacy of Shorttime TNI Treatment in Patients With COPD
Evaluation of Safety and Efficacy of Shorttime TNI Treatment in Patients with COPD Acute testing of oxygen demand using TNI vs. standard oxygen application in stable COPD patients An investigator-initiated, prospective, controlled, multicenter study
TNI, the nasal insufflation of a high flow of warm, humidified air, is an extremely
comfortable and uncomplicated alternative to numerous other approaches in non-invasive
ventilation (NIV). Up to now, NIV therapy could only be applied by masks with the associated
complications as patients could not tolerate high airflow delivered by a thin nasal cannula
without humidification and warming, thus causing concomitant negative effects. The new
therapy TNI shows a high rate of acceptance by children, too.
At present, there are two different types of devices available for nasal insufflation in
clinics:
TNI 20s, an air humidifier for clinical compressed air, and the TNI20 oxy, an air humidifier
for clinical compressed air, which can be combined with oxygen.
TNI 20 oxy The system, which is unique throughout the world, is optimized for the
application of flows of up to 20L/min and fulfils the minimum requirements of the "American
Society of Testing and Materials" for a high flow air humidifier in the non-invasive
application of 10 mg H2O/L (equivalent to about 60% rel. humidity at an ambient temperature
of 22°C) for the air humidity. The warming of the air flow by 5-15°C can be adjusted
relative to the ambient temperature. Condensation is prevented in the nasal applicator by
heating the tube as far as the nostrils. The device automatically controls humidity and
temperature depending on the prevailing ambient conditions. The TNI®20s can be attached to
the hospital infrastructure by means of a standard pressure regulator.
;
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT03662438 -
HOPE (Home-based Oxygen [Portable] and Exercise) for Patients on Long Term Oxygen Therapy (LTOT)
|
N/A | |
Completed |
NCT02221440 -
Maternal Oxygen Administration for Fetal Distress
|
N/A | |
Recruiting |
NCT05891886 -
Supplemental Oxygen in Pulmonary Embolism (SO-PE)
|
Early Phase 1 | |
Completed |
NCT03396094 -
Pre- and Apnoeic Oxygenation for RSI in ED
|
N/A | |
Completed |
NCT01300845 -
Trial Aiming at Assessing the Effect of Humidification on the Comfort of the Patient Receiving an Oxygen Therapy
|
N/A | |
Completed |
NCT03764696 -
Maternal Oxygen Administration for Fetal Distress II
|
N/A | |
Completed |
NCT03319602 -
Effect of a Modified Oxygen Mask Associated to Nasal Prongs During a High Flow Oxygenation Method
|
N/A | |
Completed |
NCT03326830 -
Prehospital High-Flow Nasal Oxygen Therapy
|
N/A | |
Recruiting |
NCT04170062 -
Oxygen Savings With Administered Oxygen and High Flow Ambient Air At Rest
|
N/A | |
Completed |
NCT03495947 -
High Flow Nasal Cannula in Immediately Post Extubation
|