Tissue Oxygen Use With Combined Arteriovenous Noninvasive Oximetry

Oxygen Consumption Clinical Trial

— TOUCAN-1  

Official title:

Tissue Oxygen Use With Combined Arteriovenous Noninvasive Oximetry (TOUCAN-1): Determining the Precision and Accuracy of Combined Finger Pulse Oximetry and Jugular Transreflectance Oximetry to Estimate Global Oxygen Use

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06072755
• Other study ID #: 2023-1317
• Secondary ID: SMPH/ANESTHESIOL
• Status: Recruiting
• Start date: January 11, 2024
• Est. completion date: October 2024

Study information

• Verified date: January 2024
• Source: University of Wisconsin, Madison
• Contact: Aaron S Hess, MD, PhD
• Phone: 608-263-8100
• Email: ahess5[@]wisc.edu
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The goal of this observational study is to find out if researchers can measure oxygen consumption in the body without having to draw blood from lines in arteries and central veins.

Participants will undergo measurements of arterial blood oxygen saturation using both finger and neck pulse oximeters.

Description:

TOUCAN-1 is a study to estimate the accuracy and precision of pulse oximetry as a noninvasive tool for oxygen consumption measurement. Researchers will use a pair of commercially-available, noninvasive pulse oximeters to estimate the oxygen saturation of blood in the internal jugular vein, and compare it to the directly measured oxygen saturation in sampled jugular blood. Researchers will then measure the arterial oxygen saturation in a finger, and compare it to the directly measured oxygen saturation in sampled radial arterial blood.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 50
• Est. completion date: October 2024
• Est. primary completion date: October 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Inpatient at the University of Wisconsin University Hospital

• Has an internal jugular venous central line

• Has a radial arterial line

Exclusion Criteria:

• Currently receiving extracorporeal membrane oxygenation (ECMO)

• Currently receiving continuous renal replacement therapy (CRRT/CVVH)

• All usable lumens of the participant's jugular catheter are in use, and interruption of any medical or therapy through any lumen would, in the view of the primary care team, compromise the participant's care.

• Jugular venous catheter is not functional or position is not confirmed by radiography

• Arterial cannula is not functional

• Known history of sickle cell anemia or other hemoglobinopathy

• Therapy with any of the following medications:

• Nitroprusside

• Hydroxocobalamin

• Indocyanine green

• Norepinephrine

• Vasopressin

• Epinephrine

• Any other medication or therapy that, in the judgement of the study investigators, may affect the accuracy and precision of the noninvasive oximetry results

Related Conditions & MeSH terms

• Oxygen Consumption

Intervention

Device:
• Finger pulse oximetry probe
This finger probe will be used to make noninvasive measurements of systemic arterial and central venous oxygen saturations.
• Transreflectance oximetry probe
This neck probe will be used to make noninvasive measurements of systemic arterial and central venous oxygen saturations.

Locations

Country	Name	City	State
United States	University of Wisconsin	Madison	Wisconsin

Sponsors (1)

Lead Sponsor	Collaborator
University of Wisconsin, Madison

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Accuracy of digital pulse oximetry	Difference in the standard deviation of the arteriovenous saturation difference comparing noninvasive photoplethysmography to invasive blood sampling and oximetry	Through study completion, approximately 20 minutes
Primary	Accuracy of jugular pulse oximetry	Difference in the standard deviation of the arteriovenous saturation difference comparing noninvasive photoplethysmography to invasive blood sampling and oximetry	Through study completion, approximately 20 minutes