Overfeeding and Exercise Clinical Trial
Official title:
Effects of Short-term Overfeeding With or Without Exercise on 24-hour Fat Oxidation and Fat Balance Before and After 10 Weeks of Training - The FeedEX Study
Rationale: Body weight is not well regulated in all individuals. In an obesogenic
environment, where overeating is common, some individuals are more prone to weight gain and
therefore overweight than others. Yet, the reasons behind this are unclear. "Resistant"
individuals often have higher physical activity levels (PALs). It seems that - at higher
levels of physical activity and therefore energy expenditure - satiety signals are more
precisely regulated, making one better at matching energy intake with expenditure. In other
words, active people may not overeat where sedentary people would. However, this does not
explain the differences in weight gain observed when subjects all have to overeat (imposed
overfeeding). It could be that active people are better able to cope metabolically with the
extra calories because of already higher levels of carbohydrate and fat oxidation compared
to their inactive counterparts.
Objectives: 1/ To study the effects of overfeeding (normal diet composition) on substrate
balance and oxidation and more specifically fat balance and oxidation; 2/ to study the
effects of exercise and training on fat oxidation during overfeeding (normal diet
composition).
Study design: This controlled intervention study will follow a cross-over design. Each
subject will spend 5 nights and 4 days in a respiration chamber on two occasions, separated
by a 10-week training period.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science