Association Between Metabolic Syndrome and Serum Nerve Growth Factor Levels in Women With Overactive Bladder — NGF  

Overactive Bladder Clinical Trial

Official title: Association Between Metabolic Syndrome and Serum Nerve Growth Factor Levels in Women With Overactive Bladder

Status Recruiting

Clinical Trial Summary

Nerve growth factor (NGF-R) receptors are between the detrusor muscle fibers and can cause afferent signals. Metabolic syndrome and obesity have been advocated to be risk factors for the development of overactive bladder.

Clinical Trial Description

Overactive bladder is a clinical syndrome characterized urgency, frequency and nocturia. Infection or other obvious causes must be excluded. The overactive bladder is loss of inhibition of the detrusor muscle during the filling or emptying of the bladder.

Specific receptors and neurotransmitters have role in development of overactive bladder. These includes adrenergic, cholinergic, non-adrenergic, non-cholinergic receptors and interstitial cells.

Nerve growth factor (NGF-R) receptors are between the detrusor muscle fibers and can cause afferent signals. Metabolic syndrome and obesity have been advocated to be risk factors for the development of overactive bladder. The investigators believe that our findings will shed light on treatment. ;

Study Design

Observational Model: Case-Only, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Metabolic Syndrome X
• Overactive Bladder
• Urinary Bladder, Overactive

• NCT number: NCT02335853
• Study type: Observational
• Source: Bakirkoy Dr. Sadi Konuk Research and Training Hospital
• Status: Recruiting
• Phase: N/A
• Start date: January 2015
• Completion date: December 2015