Clinical Trials Logo

Clinical Trial Summary

Women delay maternity and, as a consequence, available oocyte number and their quality decrease (9-18% of all IVF patients). Different treatment protocols have been developed nevertheless none of them optimal: the number of oocytes retrieved depends on the present ones. New generation of oocytes and follicles has been defended by some authors and bone marrow seems to be involved. What seems crucial is the niche that produces paracrine signals able to activate dormant cells and to attract undifferentiated cells from other tissues (homing). This phenomenon has been described by our group in other human reproductive tissues like endometrium. The purpose of the study is to improve ovarian reserve in unfertile women with poor ovarian reserve by means of bone marrow protective capacity.

Bone marrow progenitor cells will be delivered into the ovarian artery allowing them to colonize ovarian niche.

The study hypothesis is that bone marrow progenitor cells will improve ovarian reserve differentiating themselves into germ cells or, more likely, stimulating the niche to activate dormant follicles.


Clinical Trial Description

n/a


Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms


NCT number NCT02240342
Study type Interventional
Source Hospital Universitario La Fe
Contact Antonio Pellicer, Professor
Phone +34961244000
Email pellicer_ant@gva.es
Status Recruiting
Phase N/A
Start date September 2014
Completion date March 2016

See also
  Status Clinical Trial Phase
Recruiting NCT02896023 - Predictors of Ovarian Reserve in Infertile Women Phase 4
Completed NCT01268930 - Comparison of Hemostatic Matrix and Bipolar Coagulation in Surgical Treatment of Endometriomas N/A
Completed NCT03492632 - Ovarian Reserve in Patients With Psoriasis
Withdrawn NCT02728245 - Trial Comparing Preoperative Dienogest Therapy Followed by Surgery vs. Upfront Surgery to Save Ovarian Reserve in Young Women With Ovarian Endometrioma Phase 2
Completed NCT05567731 - Effect of GnRH Agonist Treatment Protocols on Ovarian Reserve N/A
Completed NCT03989921 - Ovarian Reserve and Embryo Implantation
Recruiting NCT02995343 - Evaluation of the Ovarian Reserve in Patients Who Hypogastric Arteries and or Uterine Arteries Had Been Ligated N/A
Withdrawn NCT01966536 - CD133 Transplantation to Generate Oocytes in Poor Ovarian Reserve N/A
Recruiting NCT04151173 - Assessment of Ovarian Reserve After Laparoscopic Cystectomy Versus Aspiration/Electrocoagulation in the Treatment of Ovarian Endometrioma N/A
Enrolling by invitation NCT02377128 - Ovarian Reserve Following Bilateral Salpingectomy Versus Tubal Ligation During Cesarean Section N/A
Recruiting NCT03620838 - Endometrioma Per se Versus Treatment Related Reduction in Ovarian Reserve (ERROR-2 Trial)
Completed NCT02009228 - Single-port LC Might be Preferable for Managing Ovarian Dermoid Cyst. Phase 3
Completed NCT04762615 - Impact of Underlying Renal Disease and Immunosuppressive Regimen on Ovarian Reserve in Renal Patients
Recruiting NCT03009370 - The Effect of the Ovarian Reserve on the Recurrent Pregnancy Loss N/A
Completed NCT03621683 - Antioxidants vs. Ovarian Bio-stimulation Therapy to Rescue the Ovarian Reserve N/A
Completed NCT04058678 - Effects of Telomerase Reactivation With Danazol in Ovarian Function. N/A
Recruiting NCT05743218 - Clinical Efficacy of Acupuncture on the Liver Meridian in Women With Diminished Ovarian Reserve N/A
Recruiting NCT04487925 - Controlled Ovarian Stimulation Versus Modified Natural Cycles in Poor Responders Phase 4
Terminated NCT01114464 - Impact of Chemotherapy on Ovarian Reserve in Young Women With Breast Cancer N/A
Active, not recruiting NCT00928044 - The Impact of Gynecological Surgery on Ovarian Function in Women of Reproductive Age: Postoperative Changes of Serum Anti-Müllerian Hormone (AMH) N/A