Ovarian Reserve Clinical Trial
Official title:
Ovarian Rejuvenation: Regeneration of Ovarian Follicles in Women With Poor Ovarian Reserve by Autologous Transplantation of Bone Marrow Derived Progenitors Cells in Peripheral Blood. Pilot Study.
Women delay maternity and, as a consequence, available oocyte number and their quality
decrease (9-18% of all IVF patients). Different treatment protocols have been developed
nevertheless none of them optimal: the number of oocytes retrieved depends on the present
ones. New generation of oocytes and follicles has been defended by some authors and bone
marrow seems to be involved. What seems crucial is the niche that produces paracrine signals
able to activate dormant cells and to attract undifferentiated cells from other tissues
(homing). This phenomenon has been described by our group in other human reproductive
tissues like endometrium. The purpose of the study is to improve ovarian reserve in
unfertile women with poor ovarian reserve by means of bone marrow protective capacity.
Bone marrow progenitor cells will be delivered into the ovarian artery allowing them to
colonize ovarian niche.
The study hypothesis is that bone marrow progenitor cells will improve ovarian reserve
differentiating themselves into germ cells or, more likely, stimulating the niche to
activate dormant follicles.
n/a
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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