Clinical Trials Logo

Ovarian Reserve clinical trials

View clinical trials related to Ovarian Reserve.

Filter by:
  • Withdrawn  
  • Page 1

NCT ID: NCT02728245 Withdrawn - Endometriosis Clinical Trials

Trial Comparing Preoperative Dienogest Therapy Followed by Surgery vs. Upfront Surgery to Save Ovarian Reserve in Young Women With Ovarian Endometrioma

DOROSY
Start date: October 2017
Phase: Phase 2
Study type: Interventional

Randomized phase 2 trial comparing preoperative dienogest therapy followed by surgery vs. upfront surgery to save ovarian reserve in young women with ovarian endometrioma

NCT ID: NCT01966536 Withdrawn - Ovarian Reserve Clinical Trials

CD133 Transplantation to Generate Oocytes in Poor Ovarian Reserve

Start date: November 2013
Phase: N/A
Study type: Interventional

Women delay maternity and, as a consequence, available oocyte number and their quality decrease (9-18% of all IVF patients). Different treatment protocols have been developped nevertheless none of them optimal: the number of oocytes retrieved depends on the present ones. New generation of oocytes and follicles has been defended by some authors and bone marrow seems to be involved. What seems crucial is the niche that produces paracrine signals able to activate dormant cells and to attract undifferentiated cells from other tissues (homing). This phenomenon has been described by our group in other human reproductive tissues like endometrium. The purpose of the study is to improve ovarian reserve in unfertile women with poor ovarian reserve by means of bone marrow protective capacity. CD133+ cells obtained from bone marrow will be delivered into the ovarian artery allowing them to colonize ovarian niche. The study hypothesis is that CD133+ cells will improve ovarian reserve differentiating themselves into germ cells or, more likely, stimulating the niche to activate dormant follicles.