The Effects of Hemodilution Methods in Patients Undergoing Primary Debulking Gynaecological Surgery

Ovarian Neoplasm Epithelial Clinical Trial

Official title: The Effects of Two Hemodilution Methods on Vascular Endothelial Function in Patients Undergoing Primary Debulking Gynaecological Surgery

Status Completed

Clinical Trial Summary

Primary cytoreductive surgery for ovarian cancer is an ideal setting to evaluate endothelial function under ANH and AHH, as the procedure is associated with moderately high blood loss. As the technique has not yet been described in this setting, investigators designed a pilot study to evaluate ANH and AHH in patients planned to undergo primary cytoreduction during perioperative period, with the intent of proceeding to a randomized trial if results were favorable.

Clinical Trial Description

Using a computer-generated random number table, patients were randomized to three groups: Control Group(n=30), ANH Group(n=30) and AHH Group(n=30). Patients underwent standard preoperative preparation for cytoreductive surgery according to institutional standards.All patients who underwent a standard anesthesia protocol and similar surgical procedures were considered for the analysis. For this purpose, investigators only included patients who underwent the following interventions: radical hysterectomy, bilateral adnexectomy, one or more bowel resection, peritonectomy, pelvic lymphadenectomy and extended periaortic lymphadenectomy. The patient would be ruled out of the experiment when the participant was accompanied with any kind of serious complications such as wakening delay and drug allergy. ;

Related Conditions & MeSH terms

• Ovarian Neoplasm Epithelial
• Ovarian Neoplasms

• NCT number: NCT06103214
• Study type: Interventional
• Source: Zhejiang Cancer Hospital
• Status: Completed
• Phase: N/A
• Start date: January 1, 2017
• Completion date: January 31, 2023