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Ovarian Insufficiency, Primary clinical trials

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NCT ID: NCT05443282 Completed - Oxidative Stress Clinical Trials

Ovarian Reserve and Matrix Metalloproteinases

Start date: August 10, 2021
Phase:
Study type: Observational

Primary Ovarian Insufficiency (POI) is dysfunction of ovaries before 40 years of age. It has been reported that genetic factors, endocrine disorders, previous pelvic surgeries, chemotherapy and radiotherapy, and autoimmune mechanisms play a role in 10%, however the etiology has not been clarified in 90% of the cases. Oxidative stress and autoimmunity has been shown to be responsible in the etiopathogenesis of POI. Prolidase is an imidodipeptidase. Prolidase was shown to be related with oxidative stress and autoimmune diseases in previous studies. In addition, it is thought that the level of prolidase plays a role both in the etiopathogenesis and progression of diseases. This study aims to investigate the level of prolidase enzyme in women with POI.

NCT ID: NCT04009473 Enrolling by invitation - Menopause Clinical Trials

Stem Cell Therapy and Growth Factor Ovarian in Vitro Activation

SEGOVA
Start date: June 1, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

SEGOVA procedure includes - Stem cell therapy, G - Growth factor Platelet Plasma Rich therapy and in Vitro Activation of the ovaries.