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Clinical Trial Summary

This Phase 2, open label, study with safety lead in of oral talazoparib in combination with ZEN003694 given daily in 28-day cycles will enroll patients with recurrent ovarian, fallopian tube or primary peritoneal carcinoma.


Clinical Trial Description

This study aims to determine how effective the combination of ZEN003694 and talazoparib is based on how patients respond. ZEN003694 (and developed by Zenith Epigenetics Ltd.) has shown promising activity in the treatment of solid tumors and hematologic (blood) cancers by reducing the multiplication of cancer cells. Talazoparib is an extremely effective drug being developed for the treatment of a variety of human cancers. Talazoparib kills cancer cells by inhibiting and trapping the enzyme PARP, which is known to be involved in the development of many types of cancers. These two drugs are not FDA approved in the treatment of ovarian cancer. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05071937
Study type Interventional
Source University of Pittsburgh
Contact Josh Plasmeyer
Phone 412-648-6417
Email plassmeyerjm@upmc.edu
Status Recruiting
Phase Phase 2
Start date April 13, 2023
Completion date March 1, 2031

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