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Clinical Trial Summary

The purpose of this study is to determine if exercise preconditioning can mitigate the off target effects of chemotherapy treatment on measures of cardiovascular function, peripheral neuropathy, and quality of life.


Clinical Trial Description

While survivorship for those diagnosed with epithelial ovarian cancer has continued to improve, the significant off target effects of adjuvant and neoadjuvant chemotherapy have become more prominent. These off-target effects include increased risk of cardiovascular disease, neuropathy, and decreased quality of life. Exercise initiated prior to chemotherapy induction and continued through treatment has promise in terms of preserving VO2peak and potentially mitigating the negative cardiovascular and neuropathic effects of chemotherapy. The goal of this study is to examine the effects of initiating exercise prior to any oncologic therapy and sustaining this exercise paradigm in newly diagnosed women with ovarian cancer who are undergoing initial surgery and chemotherapy. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05029154
Study type Interventional
Source University of Virginia
Contact Siddhartha S Angadi, PhD
Phone 434-243-7466
Email [email protected]
Status Not yet recruiting
Phase N/A
Start date August 2021
Completion date October 2022

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