| Eligibility |
Inclusion Criteria:
- This study will enroll women with platinum resistant high grade serous ovarian cancer.
- This study is open to minorities as appropriate but is not designed to measure
differences in intervention effects.
- All patients must be registered for screening prior to study enrollment, however, if
biomarker testing results are not required prior to enrollment to a substudy, then
enrollment can proceed immediately. CCTG will advise sites when biomarker testing
results are required prior to substudy enrollment.
Additional Criteria To Be Met Prior To Sub-study Enrollment All patients must fulfill all
of the following criteria to be eligible for enrollment to the study. Additional
eligibility criteria and relevant timings that are specific to a substudy are listed in
each substudy specific protocol.
- Patients must have platinum resistant high grade serous carcinoma of ovarian,
fallopian tube or peritoneal origin defined as progression within 6 months of last
platinum containing chemotherapy. Histological confirmation of the original primary
tumour is required.
- All patients must have measurable disease as defined by RECIST 1.1. The criteria for
defining measurable disease are as follows:
- Chest x-ray = 20 mm
- CT scan (with slice thickness of 5 mm) = 10 mm - longest diameter
- Physical exam (using calipers) = 10 mm
- Lymph nodes by CT scan = 15 mm - measured in short axis
- Patients must have at least one disease site amendable to pre and on-treatment
biopsies and must consent to undergo these tumour biopsies.
- Prior surgery is permitted provided that a minimum of at least 28 days have elapsed
between any major surgical procedure and date of enrollment, and that wound healing
has occurred.
- Systemic Therapy:
- There is no limit to the number of prior regimens for platinum-sensitive disease.
However, patients may not have received more than one cytotoxic chemotherapy
regimen for platinum-resistant disease.
- Patients may have received non-cytotoxic therapies (excluding agents targeted by
the planned substudy). Refer to each substudy protocol for exclusions.
- Prior treatment with an immune checkpoint inhibitor (ICI) is permissible
providing the ICI was not discontinued for severe or recurrent severe toxicity
(including myocarditis, or other myocardiotoxicity, encephalitis, colitis,
diarrhea, pancreatitis, hypo/hyper thyroidism, hypopituitarism, adrenal
insufficiency, rash, autonomic neuropathy, myasthenia gravis, Guillain-Barre,
myositis/polymyositis, hepatitis, nephritis, Type 1 diabetes, thrombocytopenia)
- A minimum of 4 weeks must have elapsed between last dose of prior therapy and
enrollment.
- All reversible prior toxicity must have recovered to grade = 1 (consult CCTG in
the case of irreversible toxicity)
- Other Therapy:
• Radiation, endocrine therapy, or other non-anti-cancer investigational agents are
permitted provided a minimum of 28 days (4 weeks) have elapsed between the last dose
and enrollment. Exceptions may be made for low-dose, non-myelosuppressive radiotherapy
after consultation with CCTG.
- ECOG performance status 0 or 1 and have a life expectancy = 3 months.
- Patients must be = 18 years of age.
- All patients must have consented to:
1. Release of tumour block from their primary or metastatic tumour, if available. If
archival tissue is unavailable, a tumour biopsy is required during screening. The
centre/pathologist must have agreed to the submission of the specimen(s).
2. Pre and on treatment tumour biopsies:
- Core needle (a minimum of 6 core samples are required) or excisional biopsies or
resected tissue specimens are required.
- CCTG will advise sites when biomarker testing results are required prior to enrollment
- Patients must be willing and able to comply with scheduled visits, treatment schedule,
laboratory testing, and other requirements of the trial.
- Patients must have adequate organ and marrow function measured within 7 days prior to
enrollment including;
- Absolute neutrophils = 1.5 x 10^9/L (1500/µL)
- Platelets = 100 x 10^9/L (100 x 103/µL)
- Hemoglobin =90g/L* (10.0 g/dL) with no blood transfusions in the past 28 days.
- Bilirubin = 1.5 x ULN (upper limit of normal)**
- AST & ALT = 2.5 x ULN; if patient has liver metastases = 5.0 x ULN
- Serum creatinine or: Creatinine clearance = 1.5 x ULN / >50 mL/min
- Albumin >35 g/L (3.5 g/dL)
- INR/PTT INR < 1.7 or PTT < 4 seconds above control
- Patient consent must be appropriately obtained in accordance with applicable local and
regulatory requirements. Each patient must sign a consent form prior to enrollment in
the trial to document their willingness to participate.
- Patients must be accessible for treatment and follow up. Patients enrolled on this
trial must be treated and followed at the participating centre. This implies there
must be reasonable geographical limits (for example: 1 ½ hour's driving distance)
placed on patients being considered for this trial.
- Patient must agree to return to their primary care facility for any adverse events,
response assessments and follow-up, which may occur through the course of the trial.
- In accordance with CCTG policy, protocol treatment is to begin within 2 working days
of patient enrollment.
- Women of childbearing potential will have a pregnancy test to determine eligibility as
part of the Pre-Study Evaluation
Exclusion Criteria:
- Patients with a history of other malignancy may be eligible if curatively treated
and/or the malignancy does not affect the determination of safety or efficacy of the
investigational regimen (must be confirmed with CCTG prior to enrollment).
- Patients with uncontrolled or serious illnesses, or medical conditions which could
cause unacceptable safety risks or would not permit the patient to be managed
according to the protocol or substudy. This includes but is not limited to:
- history of intra-abdominal abscess within 3 months prior to starting treatment;
- other active infection or chronic liver disease requiring systemic therapy;
- active or known human immunodeficiency virus (HIV), hepatitis B or hepatitis C
infection on antiviral treatment or with detectable viral load;
- history of interstitial lung disease, non-infectious pneumonitis or severe
pulmonary disease exacerbated by pneumonitis or uncontrolled diseases, including
pulmonary fibrosis, acute lung disease, etc.
- clinically significant pleural, pericardial, and/or peritoneal effusion (e.g.,
effusion affecting normal organ function and/or requiring percutaneous drainage
or diuretic control);
- autoimmune disease requiring chronic steroid use;
- prior history of a stroke or transient ischemic attack within the last 6 months;
- history of significant cardiac disease within 6 months prior to starting
treatment such as myocardial infarction, unstable angina, cardiomyopathy,
congestive heart failure;
- prior allogeneic stem cell transplantation or organ transplantation.
- Central nervous system metastases
- Symptomatic uncontrolled brain metastases requiring corticosteroid treatment.
- History of spinal cord compression unless after definitive treatment the patient
has clinically stable disease (SD) for at least 28 days prior to starting
investigational agent(s).
- Pregnant or lactating (breastfeeding) women.
- Patients receiving concurrent treatment with other anti-cancer therapy or other
investigational anti-cancer agents.
- Active or prior documented autoimmune or inflammatory disorders, including:
inflammatory bowel disease (e.g. colitis or Crohn's disease), diverticulitis with the
exception of diverticulosis, celiac disease or other serious gastrointestinal chronic
conditions associated with diarrhea, systemic lupus erythematosus, Sarcoidosis
syndrome, Wegener syndrome (granulomatosis with polyangiitis), rheumatoid arthritis,
hypophysitis, uveitis, etc., within the past 3 years prior to the start of treatment.
- Patients with vitiligo, type I diabetes mellitus, residual hypothyroidism due to
autoimmune conditions only requiring hormone replacement, psoriasis not requiring
systemic treatment, or conditions considered to be of low risk for recurrence are
permitted to enroll.
- Patients must not have been administered a live vaccine = 4 weeks before enrollment.
Note: Seasonal vaccines for influenza are general inactivated vaccines and are allowed.
Intranasal vaccines are live vaccines and not allowed.
- QTc (using the Fridericia correction calculation) >470 msec or >450 msec if history of
additional risk factors for Torsade de Pointe (e.g. heart failure, hypokalemia, family
history of Long QT Syndrome) or use of concomitant medications that prolong the QT/QTc
interval.
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