Ovarian Cancer Clinical Trial
Official title:
Prognostic Value of PDL1 in Ovarian High Grade Serous Carcinoma
the main purpose is to study the prognostic effect of PDL1 in ovarian cancer especially HGSC. Therefore, in the present study the investigators analyzed the expression of PDL1in HGSC by immunohistochemistry, and results were correlated to prognosis.
this cross-sectional study on 54 specimens of primary ovarian high grade serous carcinoma
cases who attended to Oncology Centre, Mansoura University, Mansoura, Egypt in the period
from 2012 till 2019. The cases were chosen randomly. All clinicopathological data including
tumor stage (T), L.N metastases (N), metastasis (M), (FIGO) staging system, ascites,
recurrence, residual tumor, CEA level, CA125 level, and peritoneal deposits analyzed. The
investigator followed the clinical outcomes in the form of disease free survival (DFS) and
overall survival (OS). The mean duration of follow up will be 43.4 months. The OS were
calculated from the time of diagnosis to death. DFS is the time from the end of therapy to
first recurrence or metastases. the specimens were stained with PDL1 marker in pathology
department Port Said university.
Statistical analysis: Data was analyzed using SPSS software V.16. Continuous data was
presented in the form of mean (SD) or Median (min-max) according to the results of
Shapiro-Wilk testing for the assumptions of normal distributions of data. Categorical data
will be presented in the form of frequencies and percentages. Statistical significance will
be tested by Welch's t-test, or Mann-Whitney U for continuous data (with respect to presence
or absence of normal distribution of data). Also, chi square test or Fisher's Exact Test will
be performed for categorical data (with respect to the minimal expected values in the
contingencies tables). Correlations of different tumour markers will be calculated using
Spearman's rho Coefficient. Kaplan-Meier test was used to test for overall survival and
disease free survival of patients with respect to tumour expression of PDL1. Comparisons will
be done using Log Rank (Mantel-Cox). Significance level is set at 0.05.
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