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Clinical Trial Summary

A multicenter open-label phase 1/1b study to evaluate the safety and preliminary efficacy of SO-C101 as monotherapy and in combination with pembrolizumab in patients with selected advanced/metastatic solid tumors


Clinical Trial Description

This study will assess the safety and tolerability of SO-C101 administered as monotherapy and in combination with an anti-PD-1 antibody (pembrolizumab) in patients with selected relapsed/refractory advanced/metastatic solid tumors (renal cell carcinoma, non-small cell lung cancer, small-cell lung cancer, bladder cancer, melanoma, Merkel-cell carcinoma, skin squamous-cell carcinoma, microsatellite instability high solid tumors, triple-negative breast cancer, mesothelioma, thyroid cancer, thymic cancer, cervical cancer, biliary track cancer, hepatocellular carcinoma, ovarian cancer, gastric cancer, head and neck squamous-cell carcinoma, and anal cancer). ;


Study Design


Related Conditions & MeSH terms

  • Anal Cancer
  • Anus Neoplasms
  • Biliary Tract Cancer
  • Biliary Tract Neoplasms
  • Bladder Cancer
  • Carcinoma
  • Carcinoma, Hepatocellular
  • Carcinoma, Merkel Cell
  • Carcinoma, Non-Small-Cell Lung
  • Carcinoma, Renal Cell
  • Carcinoma, Squamous Cell
  • Cervical Cancer
  • Gastric Cancer
  • Head and Neck Squamous Cell Carcinoma
  • Hepatocellular Carcinoma
  • Lung Neoplasms
  • Melanoma
  • Merkel Cell Carcinoma
  • Mesothelioma
  • Mesothelioma, Malignant
  • Microsatellite Instability
  • Microsatellite Instability High
  • Non Small Cell Lung Cancer
  • Ovarian Cancer
  • Ovarian Neoplasms
  • Renal Cell Carcinoma
  • Skin Squamous Cell Carcinoma
  • Small Cell Lung Carcinoma
  • Small-cell Lung Cancer
  • Squamous Cell Carcinoma of Head and Neck
  • Stomach Neoplasms
  • Thymic Cancer
  • Thymus Neoplasms
  • Thyroid
  • Triple Negative Breast Cancer
  • Triple Negative Breast Neoplasms
  • Urinary Bladder Neoplasms
  • Uterine Cervical Neoplasms

NCT number NCT04234113
Study type Interventional
Source Sotio Biotech Inc.
Contact
Status Active, not recruiting
Phase Phase 1
Start date June 13, 2019
Completion date November 2024

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