Study Evaluating the Efficacy of Maintenance Olaparib and Cediranib or Olaparib Alone in Ovarian Cancer Patients

Ovarian Cancer Clinical Trial

— ICON9  

Official title:

International Phase III Randomised Study to Evaluate the Efficacy of Maintenance Therapy With Olaparib and Cediranib or Olaparib Alone in Patients With Relapsed Ovarian Cancer Following a Response to Platinum-based Chemotherapy

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03278717
• Other study ID #: UCL/14/0795
• Status: Recruiting
• Phase: Phase 3
• Start date: June 15, 2018
• Est. completion date: December 2023

Study information

• Verified date: June 2022
• Source: University College, London
• Contact: Ian Macdonald
• Phone: +44 (0)20 7679 9808
• Email: ctc.ICON9[@]ucl.ac.uk
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

ICON 9 will assess the efficacy, safety and tolerability of maintenance olaparib in combination with cediranib compared to maintenance olaparib alone following a response to platinum-based chemotherapy in women with relapsed platinum-sensitive ovarian, fallopian tube or peritoneal cancer. Prognostic and predictive factors will be studied from tumour and blood samples.

Description:

ICON9 is an international multicentre randomised, phase III trial assessing maintenance treatment with olaparib and cediranib or olaparib alone in women with relapsed ovarian cancer whose disease progressed more than 6 months after first line chemotherapy. Women whose disease responds to platinum chemotherapy following 3 to 4 cycles can be registered for collection of germline BRCA test results if known, and somatic BRCA testing of archival tumour specimens or secondary debulking tissue if required. Patients who have completed treatment and whose disease has responded (partial or complete) to a minimum of 4 cycles of platinum based chemotherapy will be randomised to maintenance treatment of either olaparib and cediranib or olaparib alone.

The maintenance regimen may be continued beyond radiological progression until trial closure if the patient is deemed to still be deriving clinical benefit, but must be discontinued once subsequent treatment is instituted.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 330
• Est. completion date: December 2023
• Est. primary completion date: December 2023
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 18 Years and older

Eligibility

Registration Inclusion Criteria:

1. Provision of informed consent prior to any study specific procedures and the ability to comply with the protocol for the duration of the study, including undergoing treatment and scheduled visits and examinations.

2. Females aged = 18 years with previous histologically proven diagnosis of high grade serous or endometrioid carcinoma of the

• Ovary

• Fallopian tube

• or peritoneum, progressing >6 months after day 1 of the last cycle of first-line platinum-based chemotherapy and requiring treatment with platinum-based chemotherapy on the basis of radiological evidence of disease or following surgical resection of recurrent disease.

3. Patients must have had CT or MRI proven relapsed disease (measureable or non-measureable abnormalities supported by GCIG CA125 criteria of progression), or have had debulking surgery for first relapse.

4. Patients showing evidence of response to chemotherapy mid-treatment (post 3 or 4 cycles), either by CA125 or CT/MRI scan, should be approached for ICON9 trial registration to allow for BRCA mutation status to be assessed (germline and/ or somatic). Patients who underwent surgical debulking must show no evidence of disease progression by the assessments above (CA125 and CT/MRI scan) in order to be approached for registration.

5. Prior front-line maintenance therapy with bevacizumab is permitted.

6. ECOG performance status 0-1.

7. Formalin fixed, paraffin embedded (FFPE) archival/diagnostic tumour sample or from secondary debulking surgery with adequate neoplastic cell content (>30%), must be available for central BRCA testing. For inclusion in i) the genetic HRD Test and ii) the biomarker research, patients must complete the consent form. Translational blood samples are also required, see Laboratory Manual for further details.

8. Patients should have a life expectancy = 16 weeks.

9. Postmenopausal or evidence of non-childbearing status for women of childbearing potential: negative urine or serum pregnancy test within 28 days prior to study treatment and confirmed prior to treatment on day 1.

Postmenopausal is defined as age =60 years, or:

• Amenorrheic for 1 year or more following cessation of exogenous hormonal treatments

• Luteinizing hormone (LH) and Follicle stimulating hormone (FSH) levels in the post-menopausal range for women under 50

• Radiation-induced oophorectomy with last menses >1 year ago

• Chemotherapy-induced menopause with >1 year interval since last menses

• Surgical sterilisation (bilateral oophorectomy or hysterectomy)

10. Adequately controlled blood pressure (systolic blood pressure [SBP] =140 mmHg; diastolic blood pressure [DBP] = 90mmHg) on maximum of 2 antihypertensive medications.

11. Adequately controlled thyroid function, with no symptoms of thyroid dysfunction.

Randomisation Inclusion Criteria:

1. Patients must have received at least 4 cycles, and a maximum of 6 cycles of second-line platinum-based chemotherapy.

2. In patients with measurable disease, end of treatment scans must have a RECIST v1.1 'partial response' or 'complete response' and meet one of the following CA125 requirements:

1. If the first screening CA125 value is below the ULN the patient is eligible for randomisation and a second CA125 assessment is not required.

2. If the first screening CA125 value is greater than ULN then a second assessment is required at least 7 days after the first to confirm eligibility. If the second CA125 value has risen by = 15% then the patient will not be eligible.

3. In patients with non-measurable disease, who have not undergone debulking surgery, they must have had a GCIG CA125 response to chemotherapy and meet one of the following CA125 requirements:

1. If the first screening CA125 value is below the ULN the patient is eligible for randomisation and a second CA125 assessment is not required.

2. If the first screening CA125 value is greater than ULN then a second assessment is required at least 7 days after the first to confirm eligibility. If the second CA125 value has risen by = 15% then the patient will not be eligible.

4. Patients who have had debulking surgery at first relapse must have no evidence of disease progression on imaging (CT or MRI) and meet one of the following CA125 requirements:

1. If the first screening CA125 value is below the ULN the patient is eligible for randomisation and a second CA125 assessment is not required.

2. If the first screening CA125 value is greater than ULN then a second assessment is required at least 7 days after the first to confirm eligibility. If the second CA125 value has risen by = 15% then the patient will not be eligible.

5. Expected to be able to commence treatment within 7 days post randomisation, and within 4-8 weeks post day 1 of the last cycle of chemotherapy.

6. Adequate bone marrow function as defined below:

• Absolute Neutrophil Count (ANC) = 1.5 x 109/l

• Platelet (Plt) = 90 x 109/l

• Haemoglobin (Hb) = 100g/l required and no packed blood transfusions in the 14 days prior to starting trial treatment

7. Adequate liver function as defined below:

• Serum bilirubin = 1.5 x ULN (or = 3 for cases of known Gilbert's syndrome)

• Serum transaminases =3 x ULN

• Serum transaminases = 5 x ULN if liver metastasis present

8. Adequate renal function as defined below:

• Serum creatinine = 1.5 x ULN and calculated glomerular filtration rate (GFR) =50ml/min (calculated as per local practice using Wright or Cockroft-gault formula)

9. Urine dipstick for proteinuria <2+. If urine dipstick is = 2+ on two occasions more than one week apart then a 24-hour urine must demonstrate = 1 g of protein in 24 hours or protein/creatinine ratio < 1.5.

10. Adequately controlled blood pressure (systolic blood pressure [SBP] =140 mmHg; diastolic blood pressure [DBP] = 90mmHg) on maximum of 2 antihypertensive medications.

11. Germline and/or somatic BRCA mutation status must be known prior to randomisation.

Exclusion Criteria:

1. Non-epithelial ovarian cancer, carcinosarcoma, clear cell carcinoma and mucinous carcinomas.

2. Arterial thrombotic event (including transient ischemic attack, cerebrovascular accident, and peripheral arterial embolus) within the last 12 months.

3. Patients unable to swallow orally administered medication and patients with gastrointestinal impairment that could affect ability to take, or absorption of oral medicines including sub-acute or complete bowel obstruction.

4. Clinically significant signs and/or symptoms of bowel obstruction within 3 months prior to starting treatment.

5. History of intra-abdominal abscess within 3 months prior to starting treatment (randomisation).

6. History of GI perforation. Patients with a history of abdominal fistula will be considered eligible if the fistula was surgically repaired, there has been no evidence of fistula for at least 6 months prior to starting treatment, and patient is deemed to be at low risk of recurrent fistula.

7. Symptomatic or clinically significant inflammatory bowel disease (Crohn's disease or ulcerative colitis).

8. Patients with an ileostomy will be excluded.

9. Evidence of severe or uncontrolled cardiac disease.

1. Myocardial infarct or unstable angina within the last 6 months

2. New York Health Association (NHYA) = grade 2 congestive heart failure

3. Cardiac ventricular arrhythmias requiring medication

4. History of 2nd or 3rd degree atrioventricular conduction defects

10. Resting ECG with QTcF > 470msec on 2 or more time points within a 24 hour period or family history of long QT syndrome.

11. Evidence of active bleeding or bleeding diathesis.

Significant haemorrhage of >30ml in a single episode within the last 3 months or any haemoptysis (>5ml fresh blood in last 4 weeks).

12. Malignancy treated within the last 5 years except: adequately treated non-melanoma skin cancer, curatively treated in situ cancer of the cervix, ductal carcinoma in situ (DCIS) of the breast, Stage 1, grade 1 endometrial carcinoma.

13. Previous treatment with VEGFR tyrosine kinase inhibitors or PARP inhibitors are not permitted.

14. Patients with a known hypersensitivity to excipients of cediranib or olaparib.

15. Persisting = grade 2 CTCAE toxicity (except alopecia and neuropathy) from previous anti-cancer treatment.

16. Major surgery within 14 days before anticipated start of treatment and patients must have recovered from any effects of major surgery.

17. Inability to attend or comply with treatment or follow-up scheduling.

18. Evidence of any other disease, metabolic dysfunction, physical examination finding or laboratory finding giving reasonable suspicion of a disease or condition that contra-indicated the use of an investigation drug or puts the patients at high risk for treatment-related complications.

19. Pregnant or breast-feeding women are excluded. Women of childbearing potential will be excluded unless effective methods of contraception are used from signing of the informed consent, throughout the period of taking study treatment and for at least 6 weeks after last dose of trial drug(s).

20. Treatment with any other investigational agent, or participation in another interventional clinical trial within 28 days prior to enrolment (randomisation).

21. Concomitant use of known strong CYP3A4 inhibitors (such as systemic ketoconazole, itraconazole, protease inhibitors boosted with ritonavir or cobicistat, indinavir, saquinavir, nelfinavir, boceprevir, telaprevir, telithromycin and clarithromycin or moderate CYP3A inhibitors (e.g. systemic Ciprofloxacin, erythromycin, diltiazem, fluconazole, verapamil). The required washout period prior to starting olaparib is 2 weeks.

22. Concomitant use of known strong (e.g. phenobarbital, enzalutamide, phenytoin, rifampicin, rifabutin, rifapentine, carbamazepine, nevirapine and St John's Wort) or moderate CYP3A inducers (eg. bosentan, efavirenz, modafinil). The required washout period prior to starting olaparib is 5 weeks for enzalutamide or phenobarbital and 3 weeks for other agents.

23. Patients with myelodysplastic syndrome/acute myeloid leukaemia.

24. Other psychological, psychiatric, social or medical condition, physical examination finding or a laboratory abnormality that the Investigator considers would make the patient a poor trial candidate or could interfere with protocol compliance or the interpretation of trial results.

25. Patients with known active hepatitis (i.e. Hepatitis B or C) due to risk of transmitting the infection through blood or other body fluids.

26. Immunocompromised patients e.g., patients who are known to be serologically positive for human immunodeficiency virus (HIV) and are receiving antiviral therapy.

27. Patients with symptomatic uncontrolled brain or meningeal metastases. A scan to confirm the absence of brain metastases is not required. The patient can receive a stable dose of corticosteroids before and during the study as long as these were started at least 4 weeks prior to treatment.

28. Patients with spinal cord compression unless considered to have received definitive treatment for this and evidence of clinically stable disease for 28 days.

29. Previous allogenic bone marrow transplant or double umbilical cord blood transplantation (dUCBT).

Related Conditions & MeSH terms

• Carcinoma, Ovarian Epithelial
• Ovarian Cancer
• Ovarian Neoplasms

Intervention

Drug:
• Olaparib
Olaparib is a PARP inhibitor, targeting DNA repair processes.
• Cediranib
Cediranib is an inhibitor of vascular endothelial growth factor-A (VEGF), targeting angiogenesis.

Locations

Country	Name	City	State
Australia	Border Medical Oncology	Albury
Australia	Flinders Medical Centre	Bedford Park
Australia	Pindara Private Hospital	Benowa
Australia	Chris O'Brien Lifehouse	Camperdown
Australia	Canberra Hospital	Canberra
Australia	Monash Health	Clayton
Australia	Gosford Hospital	Gosford
Australia	Royal Hobart Hospital	Hobart	Tasmania
Australia	Peter MacCallum Cancer Centre	Melbourne
Australia	ICON Cancer Centre	South Brisbane
Australia	Mater Cancer Centre	South Brisbane
Australia	Calvary Mater Hospital	Sydney	New South Wales
Australia	Campbelltown Hospital	Sydney	New South Wales
Australia	Prince of Wales Hospital	Sydney	New South Wales
Australia	Townsville Hospital	Townsville
Australia	Westmead Hospital	Westmead
Canada	Cross Cancer Institute	Edmonton
Canada	Centre Hospitalier de L'Universite de Montreal	Montréal
Canada	CHU de Quebec	Québec
Canada	Princess Margaret Cancer Centre	Toronto
Canada	Sunnybrook Hospital	Toronto
Canada	BC Cancer Vancouver	Vancouver
Canada	BC Cancer Victoria	Victoria
New Zealand	Auckland City Hospital	Auckland
New Zealand	Christchurch Hospital	Christchurch
United Kingdom	Furness General Hospital	Barrow In Furness
United Kingdom	Belfast City Hospital	Belfast
United Kingdom	Royal Sussex County Hospital	Brighton
United Kingdom	Addenbrookes Hospital	Cambridge
United Kingdom	Kent & Canterbury Hospital	Canterbury
United Kingdom	Velindre Cancer Centre	Cardiff
United Kingdom	Cheltenham General Hospital	Cheltenham
United Kingdom	University Hospital Coventry	Coventry
United Kingdom	Ninewells Hospital	Dundee
United Kingdom	Western General Hospital	Edinburgh
United Kingdom	Beatson West of Scotland Cancer Centre	Glasgow
United Kingdom	Royal Surrey County Hospital	Guildford
United Kingdom	Royal Lancaster Infirmary	Lancaster
United Kingdom	Guy's Hospital	London
United Kingdom	Hammersmith Hospital	London
United Kingdom	Mount Vernon Cancer Centre	London
United Kingdom	Royal Marsden NHS Foundation Trust	London
United Kingdom	University College London Hospital	London
United Kingdom	The Christie Hospital	Manchester
United Kingdom	Queen Elizabeth the Queen Mother Hospital	Margate
United Kingdom	Churchill Hospital	Oxford
United Kingdom	Queen Alexandra Hospital	Portsmouth
United Kingdom	Royal Berkshire Hospital	Reading
United Kingdom	Southampton General Hospital	Southampton
United Kingdom	Lister Hospital	Stevenage
United Kingdom	Singleton Hospital	Swansea
United Kingdom	Musgrove Park Hospital	Taunton
United Kingdom	Royal Cornwall	Truro
United Kingdom	Clatterbridge Cancer Centre	Wirral

Sponsors (1)

Lead Sponsor	Collaborator
University College, London

Countries where clinical trial is conducted

Australia,  Canada,  New Zealand,  United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Progression free survival (PFS) measured from the date of randomisation to the date of objective progression (investigator assessed using RECIST v1.1) or date of death from any cause (in the absence of progression)	Progression free survival (PFS) measured from the time of randomisation.	3 years
Secondary	Toxicity	Toxicity (AEs) experienced by patients as assessed by the Common Terminology Criteria for Adverse Events v4.03	3 years
Secondary	PFS and OS measured from the time of starting chemotherapy	PFS and OS measured from the time of starting chemotherapy	3 years
Secondary	Adherence to maintenance therapy- compliance and dose reductions and interruptions	Adherence to maintenance therapy- compliance and dose reductions and interruptions	3 years
Secondary	TSST (the time from randomisation to start of second subsequent therapy or death)	TSST (the time from randomisation to start of second subsequent therapy or death)	3 years
Secondary	Quality of life using EORTC QLQ C30	Quality of life using EORTC QLQ C30	3 years
Secondary	Quality of life using EORTC QLQ OV28	Quality of life using EORTC QLQ OV28	3 years
Secondary	Cost effectiveness using EQ-5D-5L for economic evaluation	Cost effectiveness using EQ-5D-5L for economic evaluation	3 years
Secondary	VIII. Response rate (RECIST v1.1 and/or CA125) at 16 weeks of treatment in patients who had RECIST v1.1 measurable disease or elevated CA125 at randomisation. RECIST measurements will be based on investigator assessment not central review	VIII. Response rate (RECIST v1.1 and/or CA125) at 16 weeks of treatment in patients who had RECIST v1.1 measurable disease or elevated CA125 at randomisation. RECIST measurements will be based on investigator assessment not central review	3 years
Secondary	Overall survival (OS) measured from the date of randomisation to the date of death from any cause	Overall survival (death from any cause) measured from the time of randomisation.	3 years