Ovarian Cancer Clinical Trial
Official title:
IClyCO Influence of Chemotherapy (Carboplatin and Taxol) on the ex Vivo Expansion and Functional Capacity of Gamma-delta T Cells in Patients With Epithelial Ovarian Cancer
In patients with an ovarian cancer, the treatment is currently based on surgery and
chemotherapy.
The impact of chemotherapy on the expansion and functional abilities of Vgamma9Vdelta2 T
cells has never been evaluated.
The long term goal is to give a rational to combine conventional treatment of ovarian cancer
with immunotherapy based on Vgamma9Vdelta2 T cells.
Ovarian cancer is associated with a high mortality rate. Treatment of ovarian cancer is
currently based on surgery and chemotherapy.
The first surgery is a radical surgical procedure aiming to achieve no residual disease.
Patients who could not benefit from the first surgery may be offered neoadjuvant
chemotherapy with a new surgical procedure after 3 or 6 chemotherapy cycles. Chemotherapy is
currently based on Taxol and Carboplatin. Immunotherapy based on Vgamma9Vdelta2 T cells
could provide a promising therapeutic strategy, however, the impact of chemotherapy on the
expansion and functional abilities of Vgamma9Vdelta2 T cells has never been evaluated.
We want to study the effect of chemotherapy of ovarian cancer on Vgamma9Vdelta2 T cells
rates in the peripheral blood of patients with ovarian cancer.
Functional abilities of the Vgamma9Vdelta2 T cells will be studied: expansion after
chemotherapy and their cytotoxic abilities in an autologous context before or after
chemotherapy.
The long term goal is to give a rational to combine conventional treatment of ovarian cancer
with non-conventional treatment such as immunotherapy based on Vgamma9Vdelta2 T cells.
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Observational Model: Cohort, Time Perspective: Prospective
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