Ovarian Cancer Clinical Trial
Official title:
An Open-label, Multicenter, Non-Comparative Phase II Study of the Combination of Intravenous Topotecan and Gemcitabine Administered Once Weekly for Three Weeks Every 28 Days as Second-line Treatment in Patients With Recurrent Platinum Sensitive Ovarian Cancer
This research study was designed to determine the effectiveness of the drug, topotecan,
given intravenously (into a vein) together with the drug gemcitabine in patients with
recurrent platinum-sensitive ovarian, fallopian or primary peritoneal cancer, as well as
tumors of mixed mullerian origin. Additional purposes are to determine the long term outcome
and side effects of this combination treatment.
Since topotecan and gemcitabine have different mechanisms of action, the combination of
these 2 drugs may provide better results than either drug alone. Prior studies suggest that
the combination of topotecan and gemcitabine improves the effects on the tumor and also
appeared to be well tolerated.
n/a
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