Ovarian Cancer Clinical Trial
Official title:
Phase II Trial of Temozolomide in Patients With Cisplatin-Refractory Germ Cell Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of temozolomide in treating patients who
have metastatic germ cell tumors that have not responded to cisplatin.
OBJECTIVES: I. Determine the efficacy of temozolomide in patients with cisplatin refractory
metastatic germ cell tumors. II. Determine the safety of this treatment in these patients.
OUTLINE: Patients receive oral temozolomide on days 1-5. Treatment repeats every 28 days for
a maximum of 6 courses in the absence of disease progression or unacceptable toxicity.
PROJECTED ACCRUAL: A total of 14-25 patients will be accrued for this study over 25 months.
;
Primary Purpose: Treatment
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