Ovarian Cancer Clinical Trial
Official title:
Phase II Study of Prolonged Oral VP-16 for Advanced Ovarian Epithelial and Cervical Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of etoposide in treating patients who
have refractory, recurrent, or metastatic ovarian or cervical cancer.
OBJECTIVES: I. Determine the efficacy of prolonged oral etoposide (VP-16) in patients with
advanced ovarian epithelial or cervical cancer. II. Evaluate the frequency and severity of
observed adverse effects in this patient population treated with prolonged oral VP-16.
OUTLINE: Patients receive etoposide by mouth once daily on days 1-21 every 4 weeks. Patients
with responding disease continue treatment for up to 12 months in the absence of disease
progression or unacceptable toxicity. Patients with stable disease continue treatment for up
to 6 months in the absence of disease progression or unacceptable toxicity.
PROJECTED ACCRUAL: If 4-6 responses are observed in the first 25 patients, an additional 15
patients will be entered. The estimated duration of the study is 8 months.
;
Primary Purpose: Treatment
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