Clinical Trials Logo

Clinical Trial Summary

A prospective study validating the role of the MIRACLE2 score in patients with resuscitated out of hospital cardiac arrest in a pre-hospital setting.

Clinical Trial Description

Design: Prospective observational cohort study enrolling OOHCA patients across London in a pre-hospital setting Study Protocol: Patients with OOHCA and ROSC will be recruited from the community into the study by London Ambulance Service NHS Trust (LAS). LAS has -40 Advanced Paramedic Practitioners in Critical Care (APP-CC) who have a range of specialist skills including airway management and focused ultrasound and attend to over 1500 OOHCAs/year. Point of Care pH test: The recruited participants will have point of care pH testing performed using the CG4+ iStat system (Abbott Vascular, Illinois, U.S.A.). The test requires 2ml of venous blood and can provide blood results within minutes. The device and blood taking system have received CE marking and are already in routine use across the NHS. Once the blood results are received, the blood sample and testing system are discarded in a routine manner. Standard Care: Participants will then be conveyed to either the local emergency department or to a HAC based on current routine protocols. Patients will be treated in a routine manner after reaching secondary care in accordance with local and national guidance with no change in care based on this study. Power calculation: In 2019, APP-CCs from LAS attended to -700 OOHCA patients with ROSC. Assuming 60% recruitment, we could comfortably envisage -500 patients to be recruited in a 15 month period. From previous data, we can expect approximately 60% of the patients (n=300) to have a CPC score of 3-5 on hospital discharge. This would be of a similar size to the dataset used to derive the original score, which gave good levels of accuracy in model performance measures. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT05185063
Study type Observational
Source King's College London
Contact Nilesh Pareek, MA,MRCP,PhD
Phone 02032999000
Email [email protected]
Status Not yet recruiting
Start date March 1, 2022
Completion date March 1, 2024

See also
  Status Clinical Trial Phase
Recruiting NCT02934867 - Out of Hospital Cardiac Arrest: Trial Assessing the Survival Impact of Phone Advice N/A
Completed NCT02236819 - A Multi-centre Survey of Epidemiology, Treatment and Outcome of Patients Suffering an Out-of-hospital Cardiac Arrest
Completed NCT03743584 - Hypothermia After Cardiac Arrest - Effects on Myocardial Function and Inflammatory Response. N/A
Completed NCT02010151 - Dispatcher-Activated Neighborhood Access Defibrillation and Cardiopulmonary Resuscitation N/A
Completed NCT02292147 - Functional Outcome After Cardiac Arrest
Completed NCT01372748 - Continuous Chest Compressions vs AHA Standard CPR of 30:2 Phase 4
Completed NCT01818388 - COOL-ARREST Pilot Study to Assess Intravascular Temperature Management (IVTM) in the Treatment of Cardiac Arrest
Completed NCT01528475 - Initiation of Cooling by EMS to Promote Adoption of In-hospital Hypothermia in Cardiac Arrest Survivors N/A
Recruiting NCT04431661 - CAOCT: Intra CoronAry Optical Computerized Tomography in out-of Hospital Cardiac Arrest Patients
Completed NCT02142387 - Effects of a New Dispatcher-Assisted Basic Life Support Training Program N/A
Completed NCT01689077 - Time-differentiated Therapeutic Hypothermia N/A
Unknown status NCT02007499 - Pre-arrival Instructions Effect on Bystander Cardiopulmonary Resuscitation (CPR). N/A
Active, not recruiting NCT02401633 - Compression Only-CPR Versus Standard-CPR N/A
Completed NCT02090218 - I-Gel in Out-of-hospital Cardiac Arrest in Norway N/A
Completed NCT03065946 - Therapeutic Hypothermia and eArly Waking
Not yet recruiting NCT02587494 - Cardiac Catheterization in Cardiac Arrest N/A
Recruiting NCT02637258 - Can Optic Nerve Sheath Diameter Measurement Predict Negative Neurological Outcome ? N/A
Completed NCT03312296 - Definite Stent Thrombosis in Comatose Out of Hospital Cardiac Arrest Survivors