Out-Of-Hospital Cardiac Arrest Clinical Trial
— Geodata-BLSOfficial title:
Geographical Association Between Basic Life Support Courses, Bystander Cardiopulmonary Resuscitation and Survival
Verified date | July 2020 |
Source | Emergency Medical Services, Capital Region, Denmark |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational [Patient Registry] |
Background Since 2001 when the Danish Cardiac Arrest Registry was first established several
large-scale interventions aimed at the entire Danish population from all ages have been
initiated. BLS courses have been made mandatory in all primary schools since January 2005,
and when taking driver's license since October 2006. This has resulted in a steep increase in
the number of Danish citizens attending a BLS course to approximately 3-4.5% of the entire
population annually.
Aim The aim of this study is to investigate the effect of the numerous population-based
interventions to increase bystander basic life support (BLS) prior to arrival of Emergency
Medical Services (EMS) to persons suffering from out-of-hospital cardiac arrest (OHCA).
Further this study aim at identifying geographical areas with low frequency of Basic Life
Support (BLS) education and low level of bystander initiated BLS to enable direction of
further educational efforts in the future to increase survival.
Methods By coupling the geographical coordinates of the BLS course certificates with the GPS
coordinates of cardiac arrests, the effects of BLS courses on bystander CPR rates and
survival can be investigated. In collaboration with researchers from Aalborg University
Hospital, the entire Danish geography have been divided into digital squares of 100x100m and
combined with sociodemographic data. This data will be coupled with national administrative
parish of Denmark comprising some 2201 geographical units of approximately equal size. This
geographic model has been combined with data from the Danish Cardiac Arrest Registry, the
National Danish Patient registry and the Central Person Registry. The current study has
access to the geodata of the GPS coordinates of Danish citizens who have attained a BLS
course certificate between 2016 and 2019. By combining the two datasets in national
administrative parish's of Denmark, the investigators are able to calculate the correlation
between BLS course certificates, the rate of bystander CPR and survival of OHCA. Further, the
investigators are able to pinpoint geographic areas where improvements of the BLS education
level and bystander initiated BLS rates can be made. To involve laypersons in the current
study, focus group interviews consisting of BLS course participants will be performed to
explore the views of the attending laypersons on the project and revise accordingly.
Expected outcome To identify geographical association between bystander CPR prior to EMS
arrival and BLS training. A verified account of number of BLS certificates issued annually
and geographical visual map of first aid certificates. Finally, it is a goal to be able to
identify areas with which to start with better education. That is, areas where there is low
frequency of courses and low frequency of bystanders initiated BLS.
Status | Active, not recruiting |
Enrollment | 900000 |
Est. completion date | September 1, 2022 |
Est. primary completion date | February 1, 2022 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: All danish citizens, with a verified personal identification number, whom participated in a certified basic life support course between 2016 and 2019. Exclusion Criteria: Basic life support course participants with in-complete/faulty registered personal identification number. |
Country | Name | City | State |
---|---|---|---|
Denmark | Copenhagen Emergency Medical Services | Copenhagen |
Lead Sponsor | Collaborator |
---|---|
Emergency Medical Services, Capital Region, Denmark | Aalborg University |
Denmark,
Dansk Hjertestopsregister [Internet/in Danish]. [cited 2019 Nov 06]; Available from: http://hjertestopregister.dk/wp-content/uploads/2019/11/Dansk-Hjertestopregister-2018.pdf
Hansen CM, Lippert FK, Wissenberg M, Weeke P, Zinckernagel L, Ruwald MH, Karlsson L, Gislason GH, Nielsen SL, Køber L, Torp-Pedersen C, Folke F. Temporal trends in coverage of historical cardiac arrests using a volunteer-based network of automated external defibrillators accessible to laypersons and emergency dispatch centers. Circulation. 2014 Nov 18;130(21):1859-67. doi: 10.1161/CIRCULATIONAHA.114.008850. Epub 2014 Oct 1. — View Citation
Hansen SM, Hansen CM, Folke F, Rajan S, Kragholm K, Ejlskov L, Gislason G, Køber L, Gerds TA, Hjortshøj S, Lippert F, Torp-Pedersen C, Wissenberg M. Bystander Defibrillation for Out-of-Hospital Cardiac Arrest in Public vs Residential Locations. JAMA Cardiol. 2017 May 1;2(5):507-514. doi: 10.1001/jamacardio.2017.0008. — View Citation
Karam N, Narayanan K, Bougouin W, Benameur N, Beganton F, Jost D, Lamhaut L, Perier MC, Cariou A, Celermajer DS, Marijon E, Jouven X. Major regional differences in Automated External Defibrillator placement and Basic Life Support training in France: Further needs for coordinated implementation. Resuscitation. 2017 Sep;118:49-54. doi: 10.1016/j.resuscitation.2017.07.002. Epub 2017 Jul 5. — View Citation
Karlsson L, Malta Hansen C, Wissenberg M, Møller Hansen S, Lippert FK, Rajan S, Kragholm K, Møller SG, Bach Søndergaard K, Gislason GH, Torp-Pedersen C, Folke F. Automated external defibrillator accessibility is crucial for bystander defibrillation and survival: A registry-based study. Resuscitation. 2019 Mar;136:30-37. doi: 10.1016/j.resuscitation.2019.01.014. Epub 2019 Jan 22. — View Citation
Kragholm K, Wissenberg M, Mortensen RN, Hansen SM, Malta Hansen C, Thorsteinsson K, Rajan S, Lippert F, Folke F, Gislason G, Køber L, Fonager K, Jensen SE, Gerds TA, Torp-Pedersen C, Rasmussen BS. Bystander Efforts and 1-Year Outcomes in Out-of-Hospital Cardiac Arrest. N Engl J Med. 2017 May 4;376(18):1737-1747. doi: 10.1056/NEJMoa1601891. — View Citation
Malta Hansen C, Zinckernagel L, Ersbøll AK, Tjørnhøj-Thomsen T, Wissenberg M, Lippert FK, Weeke P, Gislason GH, Køber L, Torp-Pedersen C, Folke F. Cardiopulmonary Resuscitation Training in Schools Following 8 Years of Mandating Legislation in Denmark: A Nationwide Survey. J Am Heart Assoc. 2017 Mar 14;6(3). pii: e004128. doi: 10.1161/JAHA.116.004128. — View Citation
Perkins GD, Handley AJ, Koster RW, Castrén M, Smyth MA, Olasveengen T, Monsieurs KG, Raffay V, Gräsner JT, Wenzel V, Ristagno G, Soar J; Adult basic life support and automated external defibrillation section Collaborators. European Resuscitation Council Guidelines for Resuscitation 2015: Section 2. Adult basic life support and automated external defibrillation. Resuscitation. 2015 Oct;95:81-99. doi: 10.1016/j.resuscitation.2015.07.015. Epub 2015 Oct 15. — View Citation
Sondergaard KB, Hansen SM, Pallisgaard JL, Gerds TA, Wissenberg M, Karlsson L, Lippert FK, Gislason GH, Torp-Pedersen C, Folke F. Out-of-hospital cardiac arrest: Probability of bystander defibrillation relative to distance to nearest automated external defibrillator. Resuscitation. 2018 Mar;124:138-144. doi: 10.1016/j.resuscitation.2017.11.067. Epub 2017 Dec 5. — View Citation
TrygFonden [Internet/in Danish]. [cited 2019 Nov 06]; Available from: https://genoplivning.dk/nyt-studie-4-5-danskere-har-vaeret-paa-foerstehjaelpskursus/
Wissenberg M, Lippert FK, Folke F, Weeke P, Hansen CM, Christensen EF, Jans H, Hansen PA, Lang-Jensen T, Olesen JB, Lindhardsen J, Fosbol EL, Nielsen SL, Gislason GH, Kober L, Torp-Pedersen C. Association of national initiatives to improve cardiac arrest management with rates of bystander intervention and patient survival after out-of-hospital cardiac arrest. JAMA. 2013 Oct 2;310(13):1377-84. doi: 10.1001/jama.2013.278483. — View Citation
* Note: There are 11 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Bystander initiated CPR rate | Rate of OHCA were bystander have initiated CPR prior to arrival of EMS | 1-2 years after course | |
Primary | 30-day Survival | Survival will be defined as ROSC at the time of hospital admission. Further the investigators will include rates for 30-day survival derived with data from the National Patient Registry. | Up to 3 weeks | |
Primary | Return-of-spontaneous-circulation (ROSC) | ROSC will be defined as cases achieving ROSC anytime between recognition of the event and termination (defined as either hospital admission og declaration of death by EMS-personnel). | Up to 3 weeks | |
Primary | State at hospital admission | Defined as the case state on arrival at the hospital as either; ROSC or ongoing CPR. | 1 year |
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