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NCT03615300 Clinical Trial

Predicting Long-term Outcomes After Cardiac Arrest by Using Serum NGAL

Out-of-Hospital Cardiac Arrest Clinical Trial

Official title:
Predicting Long-term Outcomes After Cardiac Arrest by Using Serum NGAL: A Prospective, Observational Study

Clinical Trial Details — Status: Terminated

Administrative data
NCT number NCT03615300
Other study ID # UC18OESI0055
Secondary ID
Status Terminated
Phase
First received
Last updated
Start date June 28, 2018
Est. completion date May 1, 2022

Study information
Verified date May 2024
Source Uijeongbu St. Mary Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This study was performed to determine the prognosis of patients after cardiac arrest using serum markers called NGAL. The initial NGAL values of patients with post-cardiac arrest syndrome are checked by blood tests, and the long-term neurological prognosis and survival rate are collected after 6 months.

Description:

Serum NGAL is currently being used as a test to determine the likelihood of developing renal failure. However, in a previous study, serum NGAL correlated with neurological prognosis in post cardiac arrest syndrome patients. This prospective study attempts to see the role of serum NGAL as a prognostic factor by including a sufficient number of patients.

Recruitment information / eligibility
Status Terminated
Enrollment 73
Est. completion date May 1, 2022
Est. primary completion date May 1, 2022
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Adult patients who underwent targeted temperature management after out-of-hospital cardiac arrest. Exclusion Criteria: - Patients who did not survived 3 days after cardiac arrest. - Pre-existing end-stage renal disease or dependence on renal replacement therapy

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• serum NGAL
serum NGAL was measured at 0, 24, 48, and 72 hours after recovery of spontaneous circulation.

Locations
Country Name City State
Korea, Republic of Uijeongbu St. Mary's Hospital Uijeongbu-si Gyeonggi-do

Sponsors (1)
Lead Sponsor Collaborator
Uijeongbu St. Mary Hospital

Country where clinical trial is conducted

Korea, Republic of, 

References & Publications (2)

Elmer J, Jeong K, Abebe KZ, Guyette FX, Murugan R, Callaway CW, Rittenberger JC; Pittsburgh Post-Cardiac Arrest Service. Serum Neutrophil Gelatinase-Associated Lipocalin Predicts Survival After Resuscitation From Cardiac Arrest. Crit Care Med. 2016 Jan;44(1):111-9. doi: 10.1097/CCM.0000000000001357. — View Citation

Park YR, Oh JS, Jeong H, Park J, Oh YM, Choi S, Choi KH. Predicting long-term outcomes after cardiac arrest by using serum neutrophil gelatinase-associated lipocalin. Am J Emerg Med. 2018 Apr;36(4):660-664. doi: 10.1016/j.ajem.2017.12.013. Epub 2017 Dec 7 — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Long term neurologic outcome Patients' CPC score after 6 months (good outcome : CPC score 1, 2 / poor outcome : CPC score 3, 4, 5) 6 months
Secondary Proportion of participants with Overall Survival at 6 months 6-month survival rate of patients' 6 months
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