Clinical Trials Logo
  1. Home
  2. Out-of-hospital Cardiac Arrest
  3. NCT03093948

Effect of Remote Ischemic Post-conditioning on Out-of-hospital Cardiac Arrest

Out-Of-Hospital Cardiac Arrest Clinical Trial

Official title:
Effect of Remote Ischemic Post-conditioning on Neurologic and Cardiac Recovery in Out-of-hospital Cardiac Arrest

Clinical Trial Summary

Ischemia-reperfusion leads to mitochondrial injury, ion-pump injury, cell membrane damage, cytotoxic edema, and excessive oxygen free radical formation, and eventually destroys cells. Cardiac arrest is an example of global ischemia; after spontaneous circulation is restored, ischemia-reperfusion injury develops in cardiac arrest survivors. Remote ischemic postconditioning (RIPoC) involves the application of brief, reversible episodes of ischemia and reperfusion to a vascular bed or tissue, rendering remote tissues and organs resistant to ischemia-reperfusion injury. Accordingly, RIPoC has been suggested as adjunctive therapy to mitigate ischemia-reperfusion injury. RIPoC applied by repeated brief inflation-deflation of a blood pressure cuff protects against myocardial injury, and has been proven effective in acute myocardial infarction. This study aims to perform a randomized controlled trial to determine whether RIPoC has a neuroprotective effect and aids in myocardial recovery in out-of-hospital cardiac arrest patients after restoration of spontaneous circulation. Neuron-specific enolase (NSE) at 48 hours after restoration of spontaneous circulation will be measured as a primary outcome.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03093948
Study type Interventional
Source Chonnam National University Hospital
Contact
Status Terminated
Phase N/A
Start date March 21, 2017
Completion date October 21, 2019
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT05434910 - Blood Pressure and Cerebral Blood Flow After Cardiac Arrest N/A
Active, not recruiting NCT03700125 - Pre-hospital ECMO in Advanced Resuscitation in Patients With Refractory Cardiac Arrest. ( SUB30 ) N/A
Completed NCT02527694 - CPR Quality Between Flexible Stretcher and Standard Stretcher in OHCA N/A
Completed NCT02899507 - Prophylactic Antibiotics in Comatose Survivors of Out-of-hospital Cardiac Arrest Phase 4
Recruiting NCT02184468 - Survival Study After Out-of-hospital Cardiac Arrest N/A
Completed NCT04085692 - Dispatcher-Assisted CPR: Low-Dose, High-Frequency Simulation-Based Training N/A
Recruiting NCT05029167 - REstrictive Versus LIberal Oxygen Strategy and Its Effect on Pulmonary Hypertension After Out-of-hospital Cardiac Arrest (RELIEPH-study) N/A
Completed NCT04080986 - DOuble SEquential External Defibrillation for Refractory VF N/A
Completed NCT04058925 - Tissue Oxygenation During Cardiopulmonary Resuscitation as a Predictor of Return of Spontaneous Circulation
Enrolling by invitation NCT05113706 - Does Bystanders Emotional State Influence Dispatcher-assisted Cardiopulmonary?Resuscitation
Completed NCT04219306 - Machine Learning Assisted Recognition of Out-of-Hospital Cardiac Arrest During Emergency Calls. N/A
Completed NCT03881865 - P25/30 SSEPs and Neurological Prognosis After Cardiac Arrest
Recruiting NCT04993716 - Epidemiological Study on the Management of Out-of-hospital Cardiac Arrest Survivors in Champagne ArDEnnes
Completed NCT05062785 - Dose-Finding Study of Intranasal Insulin in Healthy Participants Insulin in Healthy Participants Phase 1
Recruiting NCT06122337 - Systemic Evaluation of the Etiologies of Young Adults With Non-traumatic Out-of-hospital Cardiac Arrest
Not yet recruiting NCT04584463 - Factors Associated With CPC 1-2 in 110 Patients Admitted in French ICU for a Myocardial Infarction Complicated by an OHCA.
Recruiting NCT03355885 - Early-onset Pneumonia After Out-of-hospital Cardiac Arrest N/A
Recruiting NCT05132387 - Wroclaw Out-Of-Hospital Cardiac Arrest Registry
Recruiting NCT02827422 - A Prospective, Multicenter Registry With Targeted Temperature Management After Out-of-hospital Cardiac Arrest in Korea N/A
Completed NCT02646046 - Combining Performance of Call EMS and Simultaneous Chest Compressions in a Lone Rescuer CPR N/A