Direct or Subacute Coronary Angiography in Out-of-hospital Cardiac Arrest

Status Recruiting

Clinical Trial Summary

The overall aim of this prospective, randomized study is to investigate whether acute coronary angiography (within 120 minutes) with a predefined strategy for revascularization, will improve 30-day survival in patients with out of hospital cardiac arrest with no signs of ST-elevation on ECG after Restoration of Spontaneous Circulation (ROSC). The patients will be randomized to a strategy of immediate coronary angiography within 120 minutes or to a strategy of delayed angiography that may be performed three days after the cardiac arrest.

Clinical Trial Description

The study is a prospective randomized open label multicenter study with a registry follow up in which patients with out of hospital cardiac arrest without ST-elevation on their first ECG will be randomized to either a strategy of immediate coronary angiography (treatment group) with possible coronary intervention or a strategy of delayed coronary angiography (control group). The study will include in total 1006 patients with Restoration of Spontaneous Circulation (ROSC). Randomization will be done via a web-based module after ECG is taken at the first medical contact but no later than after arrival at the emergency room. Coronary angiography should be performed within 120 minutes from randomization in the immediate angiography group. In the delayed angiography group, angiography with possible coronary intervention will be performed at the discretion of the interventional cardiologist and should preferably not be performed until three days after the cardiac arrest. This strategy is in accordance with standard practice. In case of recurrent chest pain, ST elevation, circulatory instability or cardiogenic shock, cross over to early angiography may occur. The quality of life and health economics will be evaluated at 6 months. The patients will undergo extensive neurocognitive tests and health instruments, these will be analyzed and presented. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02309151
Study type	Interventional
Source	Uppsala University
Contact	Sten Rubertsson Rubertsson, Md,PhD
Phone	+46708693996
Email	sten.rubertsson@akademiska.se
Status	Recruiting
Phase	N/A
Start date	December 2014
Completion date	December 2024

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05434910` - Blood Pressure and Cerebral Blood Flow After Cardiac Arrest	N/A
Active, not recruiting	`NCT03700125` - Pre-hospital ECMO in Advanced Resuscitation in Patients With Refractory Cardiac Arrest. ( SUB30 )	N/A
Completed	`NCT02527694` - CPR Quality Between Flexible Stretcher and Standard Stretcher in OHCA	N/A
Completed	`NCT02899507` - Prophylactic Antibiotics in Comatose Survivors of Out-of-hospital Cardiac Arrest	Phase 4
Recruiting	`NCT02184468` - Survival Study After Out-of-hospital Cardiac Arrest	N/A
Completed	`NCT04085692` - Dispatcher-Assisted CPR: Low-Dose, High-Frequency Simulation-Based Training	N/A
Recruiting	`NCT05029167` - REstrictive Versus LIberal Oxygen Strategy and Its Effect on Pulmonary Hypertension After Out-of-hospital Cardiac Arrest (RELIEPH-study)	N/A
Completed	`NCT04080986` - DOuble SEquential External Defibrillation for Refractory VF	N/A
Completed	`NCT04058925` - Tissue Oxygenation During Cardiopulmonary Resuscitation as a Predictor of Return of Spontaneous Circulation
Enrolling by invitation	`NCT05113706` - Does Bystanders Emotional State Influence Dispatcher-assisted Cardiopulmonary?Resuscitation
Completed	`NCT04219306` - Machine Learning Assisted Recognition of Out-of-Hospital Cardiac Arrest During Emergency Calls.	N/A
Completed	`NCT03881865` - P25/30 SSEPs and Neurological Prognosis After Cardiac Arrest
Recruiting	`NCT04993716` - Epidemiological Study on the Management of Out-of-hospital Cardiac Arrest Survivors in Champagne ArDEnnes
Completed	`NCT05062785` - Dose-Finding Study of Intranasal Insulin in Healthy Participants Insulin in Healthy Participants	Phase 1
Recruiting	`NCT06122337` - Systemic Evaluation of the Etiologies of Young Adults With Non-traumatic Out-of-hospital Cardiac Arrest
Not yet recruiting	`NCT04584463` - Factors Associated With CPC 1-2 in 110 Patients Admitted in French ICU for a Myocardial Infarction Complicated by an OHCA.
Recruiting	`NCT03355885` - Early-onset Pneumonia After Out-of-hospital Cardiac Arrest	N/A
Recruiting	`NCT05132387` - Wroclaw Out-Of-Hospital Cardiac Arrest Registry
Recruiting	`NCT02827422` - A Prospective, Multicenter Registry With Targeted Temperature Management After Out-of-hospital Cardiac Arrest in Korea	N/A
Completed	`NCT02646046` - Combining Performance of Call EMS and Simultaneous Chest Compressions in a Lone Rescuer CPR	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Direct or Subacute Coronary Angiography in Out-of-hospital Cardiac Arrest — DISCO

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms