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Otitis clinical trials

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NCT ID: NCT00847756 Active, not recruiting - Otitis Media Clinical Trials

Host-pathogen Interaction in Otitis Media

OMVac
Start date: April 2008
Phase: N/A
Study type: Observational

Otitis Media (OM) is one of the most frequent diseases in childhood and the primary reason for children to visit a physician. In many countries it is the most common reason to prescribe antibiotics leading to increased drug-resistance of the causative agents, or to undergo surgery. Costs for general health care are expanding, and are estimated to be 3-5 billion dollar annually in the United States. Prevention is suspected to be an important solution to this problem. Although OM management has no universal standard yet, it may imply watchful waiting, antibiotic treatment, adenoidectomy, insertion of tympanostomy tubes and (future) vaccination. Approximately 80% of the acute otitis media (AOM) cases is self-limiting within 2-14 days and also otitis media with effusion (OME) resolves spontaneously: 60% of newly detected OME resolves within 3 months. However, in a significant part of the OM population persistent or recurrent episodes of OM are responsible for a significant morbidity for both children and parents, despite variable treatment options. Through the set up of a new prospective cohort in a clinical setting, relevant patient characteristics, the role of bacterial and viral pathogens, the role of recurrent infection in relation to biofilm formation, and the host response at protein level will be studied in detail. This project is expected to increase the understanding of the underlying mechanisms of OM disease, which will support future treatment and prevention strategies. Better understanding in OM pathogenesis is warranted in order to develop these novel preventive strategies.

NCT ID: NCT00809601 Active, not recruiting - Clinical trials for Recurrent Acute Otitis Media

Study of Different Kinds of Ear Tubes

Start date: May 2008
Phase: N/A
Study type: Interventional

There are different kinds of ear tubes that may be inserted into the tympanic membrane to relieve recurrent acute otitis and hearing impairment due to otitis media with effusion. The tubes differ in size, shape and material. No-one knows if there are differences between the different kinds of tubes regarding complications. The investigators' hypothesis is that there is differences between the different kinds of tubes regarding complications. To test the investigators' hypothesis, the investigators are about to conduct a randomized controlled study of four kinds of tubes having two different material and two different shapes.

NCT ID: NCT00299455 Active, not recruiting - Acute Otitis Media Clinical Trials

Amoxicillin Clavulanate in Treatment of Acute Otitis Media

Start date: March 2006
Phase: Phase 4
Study type: Interventional

This is a prospective, randomized, double-blind, placebo controlled one-center study carried out in primary care setting of the health center of City of Turku, Finland. The study patients will be allocated to one of the two parallel treatment groups (amoxicillin-clavulanate or placebo). The hypothesis is that the symptoms and signs of acute otitis media are resolved more effectively with antimicrobial treatment than with placebo. Furthermore, this study aims at finding out prognostic factors that could help to direct antimicrobial treatment for correct subgroups of young patients.

NCT ID: NCT00271778 Active, not recruiting - Clinical trials for Chronic Otitis Media

A Comparative Study of the Outcomes of 2 Surgical Procedures for Safe Type of Chronic Otitis Media

Start date: July 2003
Phase: Phase 3
Study type: Interventional

Mastoidotympanoplasty is a recognised surgery that is performed for chronic otitis media. But whether mastoidectomy in addition to tympanoplasty is really necessary in each and every case of quiescent chronic otitis media still remains controversial. Hence this study has been undertaken to study the differences in the outcomes of the 2 surgical procedures performed for chronic otitis media in a randomized control design.

NCT ID: NCT00270660 Active, not recruiting - Clinical trials for Chronic Otitis Media

A Study of the Clinicopathologic Behaviour of the Different Types of Unsafe Chronic Otitis Media

Start date: July 2003
Phase: Phase 3
Study type: Observational

The purpose of the study is to study the clinicopathologic behaviour of the 3 dangerous types of chronic otitis media that are prone for complications. In which type are the complications more common? Which type gives rise to more hearing loss? How does the disease process in the 3 types evolve? should the 3 types of otitis media be managed differently?

NCT ID: NCT00162994 Active, not recruiting - Otitis Media Clinical Trials

Prevention Recurrent Otitis Media in the Young Children

Start date: February 2002
Phase: N/A
Study type: Interventional

The purpose of this study is to find out if young children have more benefit of the combination of adenotomy and tympanostomy than plain tympanostomy in prevention of recurrent otitis media.