Registry For Children, Adolescents And Adults With Osteosarcoma And Biologically Related Bone Sarcomas

Osteosarcoma Clinical Trial

— COSS-Registry  

Official title:

Registry For Children, Adolescents And Adults With Osteosarcoma And Biologically Related Bone Sarcomas (COSS-Registry)

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05515068
• Other study ID #: V.1.3 14.03.2022
• Status: Not yet recruiting
• Start date: September 2022
• Est. completion date: March 2032

Study information

• Verified date: August 2022
• Source: Klinikum Stuttgart
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

The Registry For Children, Adolescents And Adults With Osteosarcoma And Biologically Related Bone Sarcomas (COSS-Registry) is a non-interventional, multicentric, international, clinical and epidemiologic patient registry. The COSS-Registry collects key data on osteosarcomas or biologically related bone sarcomas. With that data collection we want to gain new scientific insights and results about this tumor disease, prognosis, surveillance and long-term effects. Besides the data collection we would also like to foster the collection of biomaterial (tumor specimen and blood samples) for scientific research. The stored material will be used to perform cell and molecular biological analyses to identify the causes of osteosarcoma, the prognosis and possible new treatment options. As a starting point the donated biomaterial of registered patients will be analyzed firstly for the presence of a tumor predisposition by germline mutations. In case of detected genetic variations that are related to the tumor disease and which may affect the patient's health and follow-up care (because of the potentially increased risk of developing other malignant tumors), affected patients will be informed and referred to genetic counseling. Registry patients will be asked at the time of diagnosis if they wish to be informed about germline variants detected as part of the study procedures.

Description:

Osteosarcomas are rare and malignant bone tumors with an incidence of only 200-300 diagnoses in Germany each year. The biological behaviour of the tumor is not well understood yet. Treatment options and survival prognosis have not improved for the last decades. The planned collection of treatment and follow-up data of affected patients at the COSS-Registry has the goal to gain further insights about this tumor, to improve survival rates and to identify possible germline variants in tumor predisposition genes in any patient diagnosed with OS. It is also necessary to foster research on the genetic and molecular biological characteristics of osteosarcoma by analyzing biomaterial samples (especially tumor tissue) for example to identify new therapy targets or to evaluate the response to and the adverse effects of chemotherapy with respect to the germline alterations. Therefore a substantial amount of biomaterial has to be gathered and stored in a biobank. Accompanying to the COSS-Registry's data collection, biological samples taken from registered patients during routine measures and which are no longer required for further treatment will be stored in the COSS-Biobank. The biological samples collected will be used to carry out genetic tests to check for an underlying tumor predisposition by germline mutations and for a next-generation sequencing of the whole genome. The goal of this project is to prospectively characterize the germline genetics in OS patients, to increase the understanding of the impact of germline alterations on the age of manifestation of OS, to evaluate the response to and the adverse effects of chemotherapy with respect to the germline alterations and to integrate germline investigation and counselling into the routine workup of any child, adolescent or young adult diagnosed with OS registered at the COSS-Registry. In this way, affected patients will benefit from their participation in the COSS-Registry and COSS-Biobank.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 1000
• Est. completion date: March 2032
• Est. primary completion date: March 2032
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• high-grade osteosarcoma (conventional and non-conventional)
• parosteal, periosteal or extraosseous osteosarcoma
• low grade central osteosarcoma
• (osseous) Undifferentiated pleomorphic sarcoma (UPS)
• (osseous) leiomyosarcoma
• (osseous) dedifferentiated chondrosarcoma
• (osseous) mesenchymal chondrosarcoma
• (osseous) fibrosarcoma
• (osseous) angiosarcoma
• informed consent

Exclusion Criteria:

• no informed consent

Related Conditions & MeSH terms

• Bone Sarcoma
• Bone Tumor
• Chondrosarcoma
• Extraskeletal Osteosarcoma
• Fibrosarcoma
• High Grade Sarcoma
• Histiocytoma, Malignant Fibrous
• Leiomyosarcoma
• Osseous Sarcoma
• Osteoblastic Osteosarcoma
• Osteosarcoma
• Parosteal Osteosarcoma
• Recurrent Osteosarcoma
• Sarcoma
• Undifferentiated Pleomorphic Sarcoma

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Klinikum Stuttgart	Klinikum Kassel GmbH (COSS-Biobank)

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Data Collection	Aims of the registry are the collection of clinical data to gain further insights about diagnosis, treatment, prognosis and risk factors of osteosarcoma and biologically related bone tumors.	20 years (There will be continous subgroup analyses through study completion.)
Secondary	Reference Diagnostics	Aim of the registry is to give the frame for reference diagnostics.	20 years (Recruitment period)
Secondary	Collection of biologic samples.	Aim of the registry is the collection of biomaterial.	20 years (Recruitment period)