Osteosarcoma Clinical Trial
Official title:
Feasibility Study of Interval Compressed Regimen Using Four-drugs for Osteosarcoma
The aim of the study is to test the feasibility of four-drug, interval-compressed regimen in
osteosarcoma.
Primary objective is to explore the toxicity and mortality related to treatment. Secondary
objectives are to examine tumor necrosis rates after neoadjuvant chemotherapy, and to
evaluate the usefulness of circulating cell-free DNA, survivin, or transforming growth
factor-beta1 levels as well as programmed cell death ligand 1 expression in tumor specimen as
a predictive or prognostic biomarker in osteosarcoma patients.
In this study, the investigators will investigate the feasibility of interval compressed regimen using four-drugs in newly-diagnosed osteosarcoma patients. Four drugs will be adriamycin, high-dose methotrexate, cisplatin, ifosfamide. All these drugs will be given preoperatively in an interval-compressed schedule, but postoperatively at a regular interval. Neoadjuvant therapy will be composed of two courses, and adjuvant therapy of two or three courses depending on necrosis rates following neoadjuvant therapy. ;
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