Osteosarcoma Clinical Trial
Official title:
Evaluation of Zoledronic Acid as a Single Agent and as an Adjuvant to Chemotherapy in the Management of High Grade Osteosarcoma
This trial will be a pilot study to find out if zoledronic acid improves the response to
chemotherapy in high grade osteosarcoma. In arm A of the study, 40 adult patients will be
randomised into two groups. One group will get standard chemotherapy and the other group
will get Zoledronic acid in addition to chemotherapy. The investigators will assess the
histological necrosis as well as disease status for up to 2 years.
In Arm B, adult patients with relapsed disease or advanced disease who are unable to take
any other therapy and are given only symptomatic care will be given 6 doses of zoledronic
acid and followed up for disease status. This will be to determine the role of zoledronic
acid as a single agent.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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