Clinical Trials Logo
  1. Home
  2. Osteoporosis, Osteopenia
  3. NCT03898024

Effects of SHR-1222 on Vascular Inflammatory Factors in Patients With Low Bone Mass

Osteoporosis, Osteopenia Clinical Trial

Official title:
Effects of SHR-1222 on Vascular Inflammatory Factors in Patients With Low Bone Mass

Clinical Trial Summary

This study aims to investigate the effects of SHR-1222 on vascular inflammatory factors in patients with low bone mass.

Clinical Trial Description

In this study, total 50 patients with low bone mass will be enrolled and divided into 5 dose groups. In the lowest dose group 6 subjects will be recruited, among whom 4 will receive SHR-1222 and the other 2 will receive placebo. In each of the other 4 groups, 11 subjects will be recruited, among whom 9 will be administered with SHR-1222 and the other 2 with placebo. Levels of nitric oxide (NO), Endothelin-1 (ET-1), plasminogen activator inhibitor-1 (PAI-1) and hypersensitivity C-reactive protein (hs-CRP) will be detected in patients before and after the SHR-1222 injection. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03898024
Study type Interventional
Source Second Xiangya Hospital of Central South University
Contact
Status Completed
Phase N/A
Start date April 15, 2019
Completion date August 15, 2020
View Details
See also
  Status Clinical Trial Phase
Completed NCT03413540 - Effects of Jumping on Bone Health in Young Women N/A
Completed NCT04037436 - Functional Exercise and Nutrition Education Program for Older Adults N/A
Recruiting NCT01844154 - Fracture and Fall Prevention in Elderly With Osteoporosis N/A
Completed NCT04169698 - Alendronate Versus Denosumab in Kidney Transplant Patients Phase 2/Phase 3
Completed NCT03408119 - Dried Plums Prevent Inflammation And Improve Bone Health in Osteopenic Men N/A
Completed NCT00330096 - Effects of Hesperidin on Bone Mineral Density and Bone Metabolism of Postmenopausal Women Phase 3
Recruiting NCT06305156 - Protocol Optimization in CT for the Quantification of BMD N/A
Completed NCT03026660 - Moringa Oleifera on Bone Density N/A
Completed NCT01153425 - µMRI of Therapeutic Intervention in Postmenopausal Osteoporosis Phase 4
Completed NCT04748250 - Effect of Soy Phytoestrogens and Acupuncture on Bone Mineral Density in Female Athlete Triad at Adolescence Age N/A
Not yet recruiting NCT03518268 - Vivomixx for Prevention of Bone Loss in Women With Breast Cancer Treated With an Aromatase Inhibitor Phase 1/Phase 2
Completed NCT04535180 - Sarcopenia and Osteoporosis in the Patients With Hemophilia
Recruiting NCT05712252 - Risk Factors for Fall and Fracture
Completed NCT03367585 - Effects of Vitamin D Supplementation in Muscle Strength and Balance Training N/A
Completed NCT03091088 - Effects of Physical Exercise to Prevent Osteoporosis in Postmenopausal Women N/A
Recruiting NCT06279078 - Long-term Effect of Steroid on Metabolic Diseases in Asthmatics
Completed NCT04526327 - Osteosarcopenia and Exercise N/A
Recruiting NCT03467035 - Role of NLRP3 Inflammasone and Hypoxia in the Severity of Osteoporosis in Patients With Bronchiectasis N/A
Not yet recruiting NCT04034199 - Treating Idiopathic Inflammatory Myopathies Related Reduced Bone Mineral Density With Denosumab or Zoledronic Acid Phase 3
Completed NCT06359353 - Effect of Pitavastatin on Bone Phase 4