Osteoporosis Fracture Clinical Trial
Official title:
Osteoporosis and Fall Prevention With Multiple Interventions in the Metropolitan Area
Verified date | January 2016 |
Source | National Taiwan University Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
OBJECTIVES To determine the effects of 3 exercise interventions on sarcopenic indices among
community-dwelling older adults with high osteoporotic fracture risks.
MATERIAL AND METHOD The current study enrolled subjects who screened high risk of fall,
osteoporosis/fracture by standardized questionnaires or FRAX. Subjects at the National Taiwan
University Hospital Bei-Hu Branch (NTUHBB) were randomized into integrated care group (ICG,
target n=50) and muscle training group (MTG, target n=50). Subjects from Lingko Chang Gung
Memorial Hospital (LCGMH) were all assigned into X-box group (XBG, target n=30). All
participants received a CD-ROM and a one education on osteoporosis, sarcopenia, frailty, fall
prevention, nutrition, and coping strategy and another hour of professional led exercise
program. ICG subjects received once weekly group exercise while MTG subjects received twice
weekly machine-based resistence training on major muscle groups. XBG subjects rececived twice
weekly exercise with X-box based programs. Major outcomes were muscle mass (measured by
bio-impedance analysis), grip strength, walking speed, and lower leg extension power at
baseline and after 12-weeks of intervention.
Status | Completed |
Enrollment | 139 |
Est. completion date | April 15, 2017 |
Est. primary completion date | October 5, 2016 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 50 Years and older |
Eligibility |
Inclusion Criteria: 1. older than 50 years of age 2. high risk as defined from one of the following criteria: - score>=1 on one minute osteoporosis risk questionnaire - 10 year predicted fracture risk >=20% for major osteoporotic fracture or >=3% for hip fracture from FRAX - fall>=2 times in pass 1 year 3. having a bone mineral density test within one year period 4. having the capability to understand the study and complete the study interventions 5. willing to participate for the intervention and study follow ups Exclusion Criteria: 1. People younger than 50 years of age 2. Could not communicate because of hearing, visual, or cognitive problems 3. Unable to stand and walk unaided (walking aids are acceptable) |
Country | Name | City | State |
---|---|---|---|
Taiwan | National Taiwan University Hospital | Taipei |
Lead Sponsor | Collaborator |
---|---|
National Taiwan University Hospital | The Taiwanese Osteoporosis Association., Wang Jhan-Yang Charitable Trust Fund |
Taiwan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Lower extremity extensor power | Lower extremity extensor power is measured by isokinetic resistance equipment by a trained research assistant with standardized protocol | 12 weeks |
Status | Clinical Trial | Phase | |
---|---|---|---|
Not yet recruiting |
NCT06024148 -
Continuation of Anti-osteoporotic Treatment 1 Year After Initial Administration
|
||
Completed |
NCT03710889 -
Early Effects of Abaloparatide on Tissue-Based Indices of Bone Formation and Resorption
|
Phase 3 | |
Recruiting |
NCT05058976 -
Romosozumab Use to Build Skeletal Integrity
|
Phase 4 | |
Completed |
NCT04960033 -
Evaluating Fracture Risk Assessment Tools (FRAX) From Different Regions in Central South Chinese Postmenopausal Women
|
||
Completed |
NCT03798444 -
Height Loss, Kyphosis Indicators, Bone Mineral Density and Vertebral Fractures in Chinese Postmenopausal Women
|
||
Completed |
NCT05366621 -
Post-fracture Medication and Mortality
|
||
Not yet recruiting |
NCT04597931 -
Evaluation of Romosozumab vs. Zoledronic Acid Effect in Patients With Spinal Cord Injury and Low Bone Mineral Density
|
Phase 4 | |
Enrolling by invitation |
NCT03178799 -
Randomized Fracture Liaison Services
|
||
Completed |
NCT02803190 -
Osteoporosis and Fall Prevention and Posture Correction Interventions in the Metropolitan Area
|
N/A | |
Recruiting |
NCT03451305 -
Postrual Reduction With Pillow in Osteoporotic Vertebral Fracture
|
N/A | |
Recruiting |
NCT03811509 -
Breast Cancer Women on Aromatase Inhibitors Treatment
|
Phase 4 | |
Recruiting |
NCT06379243 -
Development and Validation of a Postoperative Re-fracture Risk Model for Osteoporotic Spinal Fractures
|
N/A |