Post Marketing Surveillance Study of Actimmune in Patients With Severe, Malignant Osteopetrosis

Osteopetrosis Clinical Trial

Official title:

Post-Marketing Surveillance Study of Actimmune (Interferon Gamma-1b) in Patients With Severe Malignant Osteopetrosis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00043329
• Other study ID #: GIOS-003
• Status: Completed
• Phase: Phase 4
• First received: August 7, 2002
• Last updated: October 30, 2007
• Start date: January 2002
• Est. completion date: September 2005

Study information

• Verified date: October 2007
• Source: InterMune
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to establish a registry of all children with severe, malignant osteopetrosis who are treated with Actimmune (IFN-g 1b or Interferon gamma-1b) to monitor the effects of IFN-g 1b on preventing progression of this disease and to follow the safety of patients receiving it on a long-term basis. In addition, evaluation of the possible effect of Actimmune therapy on the humoral response to normal childhood vaccinations in this same patient population will be examined.Interferon gamma is a substance that the body makes naturally.

Description:

It is made by white blood cells and appears to be involved in regulating the body's ability to fight off infection. Actimmune is a synthetic form of Interferon gamma which is similar to that normally made by white blood cells.

IFN-g 1b (Actimmune®) is currently approved by the United States Food and Drug Administration (FDA) for the treatment of patients with chronic granulomatous disease (CGD) to reduce the frequency and severity of serious infections. It is also approved in patients with severe, malignant osteopetrosis to delay the time to disease progression. In research trials, IFN-g 1b has been given to over 2,000 patients in diseases such as CGD, osteopetrosis, atopic dermatitis, pulmonary fibrosis, atypical mycobacteria and various cancers.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 6
• Est. completion date: September 2005
• Accepts healthy volunteers: No
• Gender: Both
• Age group: N/A and older

Eligibility

• Male or female

• Diagnosis of severe, malignant osteopetrosis

• Currently receiving or planning to initiate therapy with Actimmune (Interferon gamma-1b)

• Willing to attend follow-up appointments every 6 months following enrollment into the study, if clinically indicated

Study Design

Time Perspective: Retrospective

Related Conditions & MeSH terms

• Osteopetrosis

Intervention

Drug:
• Actimmune Registry
as administered by physician

Locations

Country	Name	City	State
United States	InterMune, Inc.	Brisbane	California

Sponsors (1)

Lead Sponsor	Collaborator
InterMune

Country where clinical trial is conducted

United States,