Denosumab vs Zoledronate After Lumbar Fusion

Status Recruiting

Clinical Trial Summary

The aim of the study was to compare denosumab and zoledronate efficacy in bone mass, bone turnover markers (BTMs), Visual Analogue Scale (VAS) for leg and back, EuroQol Five-Dimension (EQ-5D) scores, Quality of Life Questionnaire of the European Foundation for Osteoporosis-31 (QUALEFFO-31) scores, and Roland-Morris Disability Functioning Questionnaire (RMDQ) scores, secondary fracture, complications and adverse events after lumbar fusion.

Clinical Trial Description

Lumbar degenerative disease including spinal stenosis and lumbar spondylolisthesis were the most common reason lead to older patients disability, which was the main indication for older patients to perform lumbar fusion surgery. For patients with lumbar degenerative disease older than 50 years old, a proportion of patients had osteoporosis. The trial aims to investigate whether denosumab versus zoledronate acid in osteopenic patients with lumbar fusion surgery. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05638399
Study type	Interventional
Source	Shenzhen People's Hospital
Contact	Hongyu Wang, Doctor
Phone	18241651300
Email	wanghongyu790039663@126.com
Status	Recruiting
Phase	Phase 3
Start date	January 15, 2020
Completion date	February 28, 2023

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