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Clinical Trial Summary

The aim of the study was to compare denosumab and zoledronate efficacy in bone mass, bone turnover markers (BTMs), Visual Analogue Scale (VAS) for leg and back, EuroQol Five-Dimension (EQ-5D) scores, Quality of Life Questionnaire of the European Foundation for Osteoporosis-31 (QUALEFFO-31) scores, and Roland-Morris Disability Functioning Questionnaire (RMDQ) scores, secondary fracture, complications and adverse events after lumbar fusion.


Clinical Trial Description

Lumbar degenerative disease including spinal stenosis and lumbar spondylolisthesis were the most common reason lead to older patients disability, which was the main indication for older patients to perform lumbar fusion surgery. For patients with lumbar degenerative disease older than 50 years old, a proportion of patients had osteoporosis. The trial aims to investigate whether denosumab versus zoledronate acid in osteopenic patients with lumbar fusion surgery. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05638399
Study type Interventional
Source Shenzhen People's Hospital
Contact Hongyu Wang, Doctor
Phone 18241651300
Email wanghongyu790039663@126.com
Status Recruiting
Phase Phase 3
Start date January 15, 2020
Completion date February 28, 2023

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